(Z)-2-[3-(2-benzylbenzylidene)-2-ethyl-7-hydroxy-3H-inden-1-yl]acetamide

Base Information

Chemical Name:(Z)-2-[3-(2-benzylbenzylidene)-2-ethyl-7-hydroxy-3H-inden-1-yl]acetamide
CAS No.:177362-86-6
Molecular Formula:C₂₇H₂₅NO₂
Molecular Weight:395.501
Hs Code.:

Synonyms:(Z)-2-[3-(2-benzylbenzylidene)-2-ethyl-7-hydroxy-3H-inden-1-yl]acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-2-[3-(2-benzylbenzylidene)-2-ethyl-7-hydroxy-3H-inden-1-yl]acetamide

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Technology Process of (Z)-2-[3-(2-benzylbenzylidene)-2-ethyl-7-hydroxy-3H-inden-1-yl]acetamide

There total 11 articles about (Z)-2-[3-(2-benzylbenzylidene)-2-ethyl-7-hydroxy-3H-inden-1-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: (E/Z)-2-[3-(2-benzylbenzylidene)-2-ethyl-7-methoxy-3H-inden-1-yl]acetamide

: 177362-86-6
(Z)-2-[3-(2-benzylbenzylidene)-2-ethyl-7-hydroxy-3H-inden-1-yl]acetamide

Guidance literature:: With boron tribromide; In dichloromethane;
DOI:10.1021/jm960395q

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 177362-86-6
(Z)-2-[3-(2-benzylbenzylidene)-2-ethyl-7-hydroxy-3H-inden-1-yl]acetamide

Guidance literature:: Multi-step reaction with 10 steps

1: 24 percent / C₃H₇COONa / 150 °C

2: H₂ / 10percent Pd/C / methanol / 2280 Torr

3: Br₂, AcOH / 2.5 h / Ambient temperature

4: 30.0 g / polyphosphoric acid / 2.5 h / 100 °C

5: H₂, AcONa / Pd/C

6: 1.) NaH / 1.) toluene, 0 deg C, 1 h, 2.) toluene, reflux, 4 h

7: 85 percent / conc. H₂SO₄ / CHCl₃ / 0.67 h / Heating

8: 62 percent / NaOMe / methanol / 2.67 h / Heating

9: 1.) Et₃N, benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, 2.) aq. NH₄OH / 1.) CH₃CN, RT, 45 min, 2.) CH₃CN, RT, 30 min

10: 72 percent / BBr₃ / CH₂Cl₂

With ammonium hydroxide; PPA; C₃H₇COONa; sulfuric acid; hydrogen; bromine; sodium methylate; sodium acetate; boron tribromide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; chloroform;
DOI:10.1021/jm960395q

Reference yield:

: 177363-08-5
2-ethyl-7-methoxy-1-indanone

: 177362-86-6
(Z)-2-[3-(2-benzylbenzylidene)-2-ethyl-7-hydroxy-3H-inden-1-yl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) toluene, 0 deg C, 1 h, 2.) toluene, reflux, 4 h

2: 85 percent / conc. H₂SO₄ / CHCl₃ / 0.67 h / Heating

3: 62 percent / NaOMe / methanol / 2.67 h / Heating

4: 1.) Et₃N, benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, 2.) aq. NH₄OH / 1.) CH₃CN, RT, 45 min, 2.) CH₃CN, RT, 30 min

5: 72 percent / BBr₃ / CH₂Cl₂

With ammonium hydroxide; sulfuric acid; sodium methylate; boron tribromide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In methanol; dichloromethane; chloroform;
DOI:10.1021/jm960395q