(2S,R(S))-N-(tert-butylsulfinyl)-1-[2-(2-hydroxyethyl)phenyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentan-2-amine

Base Information

• Chemical Name: (2S,R(S))-N-(tert-butylsulfinyl)-1-[2-(2-hydroxyethyl)phenyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentan-2-amine
• CAS No.: 1232683-18-9
• Molecular Formula: C₂₂H₃₇NO₄S
• Molecular Weight: 411.606
• Mol file: 1232683-18-9.mol

Synonyms:(2S,R(S))-N-(tert-butylsulfinyl)-1-[2-(2-hydroxyethyl)phenyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentan-2-amine

Chemical Property of (2S,R(S))-N-(tert-butylsulfinyl)-1-[2-(2-hydroxyethyl)phenyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentan-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (2S,R(S))-N-(tert-butylsulfinyl)-1-[2-(2-hydroxyethyl)phenyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentan-2-amine

There total 1 articles about (2S,R(S))-N-(tert-butylsulfinyl)-1-[2-(2-hydroxyethyl)phenyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

C13H25NO3S + C9H10LiO(1-)*Li(1+) → (2S,R(S))-N-(tert-butylsulfinyl)-1-[2-(2-hydroxyethyl)phenyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentan-2-amine (1232683-18-9) + (2R,R(S))-N-(tert-butylsulfinyl)-1-[2-(2-hydroxyethyl)phenyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentan-2-amine

Guidance literature:

C₉H₁₀LiO^(1-)*Li⁽¹⁺⁾; With dimethyl zinc(II); In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;

C₁₃H₂₅NO₃S; In tetrahydrofuran; at -65 ℃; for 12h; Inert atmosphere;

With water; In tetrahydrofuran; at -65 - 20 ℃; optical yield given as %de; diastereoselective reaction;

DOI:10.1002/ejoc.201000111

Reference yield:

(2S,R(S))-N-(tert-butylsulfinyl)-1-[2-(2-hydroxyethyl)phenyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentan-2-amine (1232683-18-9) → (S)-4-amino-5-[2-(2-hydroxyethyl)phenyl]pentan-1-ol (1232683-36-1)

Guidance literature:

(2S,R(S))-N-(tert-butylsulfinyl)-1-[2-(2-hydroxyethyl)phenyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentan-2-amine; With hydrogenchloride; In 1,4-dioxane; methanol; at 0 ℃; for 3h;

With sodium hydrogencarbonate; In 1,4-dioxane; methanol; water;

DOI:10.1002/ejoc.201000111

Downstream raw materials:

(S)-4-amino-5-[2-(2-hydroxyethyl)phenyl]pentan-1-ol