(S)-N-<<3-<4-(chlorosulfonyl)phenyl>2-oxo-5-oxazolidinyl>methyl> acetamide

Base Information

Chemical Name:(S)-N-<<3-<4-(chlorosulfonyl)phenyl>2-oxo-5-oxazolidinyl>methyl> acetamide
CAS No.:96800-11-2
Molecular Formula:C₁₂H₁₃ClN₂O₅S
Molecular Weight:332.765
Hs Code.:

Synonyms:(S)-N-<<3-<4-(chlorosulfonyl)phenyl>2-oxo-5-oxazolidinyl>methyl> acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-<<3-<4-(chlorosulfonyl)phenyl>2-oxo-5-oxazolidinyl>methyl> acetamide

Chemical Property:

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Technology Process of (S)-N-<<3-<4-(chlorosulfonyl)phenyl>2-oxo-5-oxazolidinyl>methyl> acetamide

There total 7 articles about (S)-N-<<3-<4-(chlorosulfonyl)phenyl>2-oxo-5-oxazolidinyl>methyl> acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 96800-17-8
(S)-N-<<3-phenyl-2-oxo-5-oxazolidinyl>methyl>acetamide

: 96800-11-2
(S)-N-<<3-<4-(chlorosulfonyl)phenyl>2-oxo-5-oxazolidinyl>methyl> acetamide

Guidance literature:: With chlorosulphuric acid; for 1h; Ambient temperature;
DOI:10.1021/jm00171a035

Reference yield:

: 62-53-3
aniline

: 96800-11-2
(S)-N-<<3-<4-(chlorosulfonyl)phenyl>2-oxo-5-oxazolidinyl>methyl> acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 2 h / 80 - 90 °C

2: 76 percent / sodium methoxide / toluene / Heating

3: 87 percent / pyridine / 15 °C

4: 88 percent / 18-crown-6, sodium azide / dimethylformamide / 5 h / 70 °C

5: 66 percent / trimethyl phosphite / 1,2-dimethoxy-ethane / 1.5 h / Heating

6: 98 percent / NaOH / H₂O; tetrahydrofuran / 0 - 5 °C

7: chlorosulfuric acid / 1 h / Ambient temperature

With pyridine; sodium hydroxide; sodium azide; chlorosulphuric acid; 18-crown-6 ether; sodium methylate; phosphorous acid trimethyl ester; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00128a003

Reference yield:

: 87508-42-7
(R)-5-(hydroxymethyl)-3-phenyl-2-oxooxazolidine

: 96800-11-2
(S)-N-<<3-<4-(chlorosulfonyl)phenyl>2-oxo-5-oxazolidinyl>methyl> acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / pyridine / 15 °C

2: 88 percent / 18-crown-6, sodium azide / dimethylformamide / 5 h / 70 °C

3: 66 percent / trimethyl phosphite / 1,2-dimethoxy-ethane / 1.5 h / Heating

4: 98 percent / NaOH / H₂O; tetrahydrofuran / 0 - 5 °C

5: chlorosulfuric acid / 1 h / Ambient temperature

With pyridine; sodium hydroxide; sodium azide; chlorosulphuric acid; 18-crown-6 ether; phosphorous acid trimethyl ester; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00128a003