Technology Process of 4-(4-methylphenoxy)-2-iodophenol
There total 4 articles about 4-(4-methylphenoxy)-2-iodophenol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1-thiopropane; sodium hydride;
In
N,N-dimethyl-formamide;
1) 100 deg C, 3 h, 2) room temperature, 3 h;
DOI:10.1021/jo00335a042
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 18 percent / copper powder, cupric acetate / dimethylformamide / 4 h / Heating
2: 1) H2, 2a) NaNO2, conc. H2SO4, 2b) sodium iodide, iodine, urea / 1) 10percent Pd-C / 1) acetic acid, ethanol, 75 psi, 2a) acetic acid, 0-5 deg C, 1 h, 2b) water, CHCl3, room temparature, 2 h
3: 63 percent / 1-propanethiol, NaH / dimethylformamide / 1) 100 deg C, 3 h, 2) room temperature, 3 h
With
1-thiopropane; sulfuric acid; hydrogen; iodine; copper diacetate; copper; sodium hydride; urea; sodium iodide; sodium nitrite;
palladium on activated charcoal;
In
N,N-dimethyl-formamide;
DOI:10.1021/jo00335a042
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 18 percent / copper powder, cupric acetate / dimethylformamide / 4 h / Heating
2: 1) H2, 2a) NaNO2, conc. H2SO4, 2b) sodium iodide, iodine, urea / 1) 10percent Pd-C / 1) acetic acid, ethanol, 75 psi, 2a) acetic acid, 0-5 deg C, 1 h, 2b) water, CHCl3, room temparature, 2 h
3: 63 percent / 1-propanethiol, NaH / dimethylformamide / 1) 100 deg C, 3 h, 2) room temperature, 3 h
With
1-thiopropane; sulfuric acid; hydrogen; iodine; copper diacetate; copper; sodium hydride; urea; sodium iodide; sodium nitrite;
palladium on activated charcoal;
In
N,N-dimethyl-formamide;
DOI:10.1021/jo00335a042
