3',5'-O-(di-tert-butylsilanediyl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)uridine

Base Information

Chemical Name:3',5'-O-(di-tert-butylsilanediyl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)uridine
CAS No.:1449578-40-8
Molecular Formula:C₂₈H₄₂N₂O₉SSi
Molecular Weight:610.801
Hs Code.:

Synonyms:3',5'-O-(di-tert-butylsilanediyl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)uridine

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Chemical Property of 3',5'-O-(di-tert-butylsilanediyl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)uridine

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Technology Process of 3',5'-O-(di-tert-butylsilanediyl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)uridine

There total 4 articles about 3',5'-O-(di-tert-butylsilanediyl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1447969-98-3
3’,5’-O-di-tert-silyl-2’-O-[(methylthio)methyl]uridine

: 212555-23-2
(2,4,6-trimethoxyphenyl)methanethiol

: 1449578-40-8
3',5'-O-(di-tert-butylsilanediyl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)uridine

Guidance literature:: 3’,5’-O-di-tert-silyl-2’-O-[(methylthio)methyl]uridine; With sulfuryl dichloride; In dichloromethane; at 20 ℃; for 0.75h;

(2,4,6-trimethoxyphenyl)methanethiol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 2h;

With potassium dihydrogenphosphate; water; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c3cc43725f

Reference yield:

: 85272-31-7
di-tert-butylsilyl bis(trifluoromethanesulfonate)

: 1449578-40-8
3',5'-O-(di-tert-butylsilanediyl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)uridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 1 h / 0 °C

2.1: acetic anhydride; acetic acid / 24 h / 20 °C

3.1: sulfuryl dichloride / dichloromethane / 0.75 h / 20 °C

3.2: 2 h

With sulfuryl dichloride; acetic anhydride; acetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3cc43725f

Reference yield:

: 58-96-8
uridine

: 1449578-40-8
3',5'-O-(di-tert-butylsilanediyl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)uridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 1 h / 0 °C

2.1: acetic anhydride; acetic acid / 24 h / 20 °C

3.1: sulfuryl dichloride / dichloromethane / 0.75 h / 20 °C

3.2: 2 h

With sulfuryl dichloride; acetic anhydride; acetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3cc43725f