(N_α-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine tert-butyl ester

Base Information

Chemical Name:(N_α-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine tert-butyl ester
CAS No.:366780-98-5
Molecular Formula:C₂₂H₃₁N₃O₆
Molecular Weight:433.505
Hs Code.:

(N<sub>α</sub>-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine tert-butyl ester

Synonyms:(N_α-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine tert-butyl ester

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Chemical Property of (N_α-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine tert-butyl ester

Chemical Property:

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Technology Process of (N_α-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine tert-butyl ester

There total 2 articles about (N_α-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 27532-96-3
glycine tert-butyl ester hydrochloride

: 366780-94-1
N_α-carbobenzyloxy-L-2-amino-5-acryloylaminopentanoic acid

: 366780-98-5
(N_α-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine tert-butyl ester

Guidance literature:: N_α-carbobenzyloxy-L-2-amino-5-acryloylaminopentanoic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; for 0.25h;

glycine tert-butyl ester hydrochloride; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/S0968-0896(01)00292-9

Reference yield:

: 2640-58-6
Nα-benzyloxycarbonyl-L-ornithine

: 366780-98-5
(N_α-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 83 percent / Et₃N / methanol / 12 h / 0 - 20 °C

2.1: EDC*HCl; Et₃N / CH₂Cl₂ / 0.25 h

2.2: 85 percent / CH₂Cl₂ / 12 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1016/S0968-0896(01)00292-9