L-(-)-norephedrine (S)-3-benzyloxycarbonylamino-4,4-dimethylpentanoic acid salt

Base Information

• Chemical Name: L-(-)-norephedrine (S)-3-benzyloxycarbonylamino-4,4-dimethylpentanoic acid salt
• CAS No.: 1159138-99-4
• Molecular Formula: C₉H₁₃NO*C₁₅H₂₁NO₄
• Molecular Weight: 430.544
• Mol file: 1159138-99-4.mol

Synonyms:L-(-)-norephedrine (S)-3-benzyloxycarbonylamino-4,4-dimethylpentanoic acid salt

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Chemical Property of L-(-)-norephedrine (S)-3-benzyloxycarbonylamino-4,4-dimethylpentanoic acid salt

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of L-(-)-norephedrine (S)-3-benzyloxycarbonylamino-4,4-dimethylpentanoic acid salt

There total 2 articles about L-(-)-norephedrine (S)-3-benzyloxycarbonylamino-4,4-dimethylpentanoic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.1%

3-benzyloxycarbonylamino-4,4-dimethylpentanoic acid (200642-84-8,872423-95-5) + (1R,2S)-norephedrine (492-41-1,58550-13-3,757124-50-8) → L-(-)-norephedrine (S)-3-benzyloxycarbonylamino-4,4-dimethylpentanoic acid salt (1159138-99-4)

Guidance literature:

In toluene; at 90 ℃; for 5h; Cooling with ice;

DOI:10.1016/j.tetasy.2009.01.018

Reference yield:

3-benzyloxycarbonylamino-4,4-dimethylpentanoic acid (200642-84-8,872423-95-5) + (1R,2S)-norephedrine (492-41-1,58550-13-3,757124-50-8) → L-(-)-norephedrine (S)-3-benzyloxycarbonylamino-4,4-dimethylpentanoic acid salt (1159138-99-4) + L-(-)-norephedrine (R)-3-benzyloxycarbonylamino-4,4-dimethylpentanoic acid salt

Guidance literature:

In acetic acid butyl ester; optical yield given as %de;

DOI:10.1016/j.tetasy.2009.01.018

Reference yield: 95.9%

L-(-)-norephedrine (S)-3-benzyloxycarbonylamino-4,4-dimethylpentanoic acid salt (1159138-99-4) → (S)-3-benzyloxycarbonylamino-4,4-dimethylpentanoic acid (1159138-98-3,872423-95-5)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; pH=2; optical yield given as %ee;

DOI:10.1016/j.tetasy.2009.01.018

upstream raw materials:

3-benzyloxycarbonylamino-4,4-dimethylpentanoic acid

(1R,2S)-norephedrine

Downstream raw materials:

(S)-3-benzyloxycarbonylamino-4,4-dimethylpentanoic acid

Refernces