N-[[5-tert-butyl-2-(3-chloro-4-fluoro-phenyl)-2H-pyrazol-3-yl]-methyl]-2-[4-(1,1-dioxo-[1,2]thiazolidin-2-yl)-3-fluoro-phenyl]-propionamide

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Chemical Name:N-[[5-tert-butyl-2-(3-chloro-4-fluoro-phenyl)-2H-pyrazol-3-yl]-methyl]-2-[4-(1,1-dioxo-[1,2]thiazolidin-2-yl)-3-fluoro-phenyl]-propionamide
CAS No.:1402581-85-4
Molecular Formula:C₂₆H₂₉ClF₂N₄O₃S
Molecular Weight:551.057
Hs Code.:

Synonyms:N-[[5-tert-butyl-2-(3-chloro-4-fluoro-phenyl)-2H-pyrazol-3-yl]-methyl]-2-[4-(1,1-dioxo-[1,2]thiazolidin-2-yl)-3-fluoro-phenyl]-propionamide

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Chemical Property of N-[[5-tert-butyl-2-(3-chloro-4-fluoro-phenyl)-2H-pyrazol-3-yl]-methyl]-2-[4-(1,1-dioxo-[1,2]thiazolidin-2-yl)-3-fluoro-phenyl]-propionamide

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Technology Process of N-[[5-tert-butyl-2-(3-chloro-4-fluoro-phenyl)-2H-pyrazol-3-yl]-methyl]-2-[4-(1,1-dioxo-[1,2]thiazolidin-2-yl)-3-fluoro-phenyl]-propionamide

There total 6 articles about N-[[5-tert-butyl-2-(3-chloro-4-fluoro-phenyl)-2H-pyrazol-3-yl]-methyl]-2-[4-(1,1-dioxo-[1,2]thiazolidin-2-yl)-3-fluoro-phenyl]-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1254713-64-8
(3-tert-butyl-1-(3-chloro-4-fluorophenyl)-1H-pyrazol-5-yl)methanamine

: 1402586-29-1
2-[4-(1,1-dioxo-[1,2]thiazolidin-2-yl)-3-fluoro-phenyl]-propionic acid

: 1402581-85-4
N-[[5-tert-butyl-2-(3-chloro-4-fluoro-phenyl)-2H-pyrazol-3-yl]-methyl]-2-[4-(1,1-dioxo-[1,2]thiazolidin-2-yl)-3-fluoro-phenyl]-propionamide

Guidance literature:: With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 48h;

Reference yield:

: 78543-07-4
ethyl 2-(3-fluoro-4-nitrophenyl)propionate

: 1402581-85-4
N-[[5-tert-butyl-2-(3-chloro-4-fluoro-phenyl)-2H-pyrazol-3-yl]-methyl]-2-[4-(1,1-dioxo-[1,2]thiazolidin-2-yl)-3-fluoro-phenyl]-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 22 °C / 1875.19 Torr

2: pyridine / dichloromethane / 1 h / 0 °C

3: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

4: lithium hydroxide; water / tetrahydrofuran / Reflux

5: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 48 h / 20 °C

With pyridine; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1402581-85-4
N-[[5-tert-butyl-2-(3-chloro-4-fluoro-phenyl)-2H-pyrazol-3-yl]-methyl]-2-[4-(1,1-dioxo-[1,2]thiazolidin-2-yl)-3-fluoro-phenyl]-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / -45 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 22 °C / 1875.19 Torr

3: pyridine / dichloromethane / 1 h / 0 °C

4: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

5: lithium hydroxide; water / tetrahydrofuran / Reflux

6: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 48 h / 20 °C

With pyridine; palladium 10% on activated carbon; potassium tert-butylate; water; hydrogen; potassium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;