(S)-tert-butyl (1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)carbamate

Base Information

• Chemical Name: (S)-tert-butyl (1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)carbamate
• CAS No.: 1615255-01-0
• Molecular Formula: C₂₃H₂₆ClN₃O₃
• Molecular Weight: 427.931

Synonyms:(S)-tert-butyl (1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)carbamate

Chemical Property of (S)-tert-butyl (1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (S)-tert-butyl (1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)carbamate

There total 2 articles about (S)-tert-butyl (1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

t-Boc-L-valine (13734-41-3) + 2-chloro-6-aminobenzoic acid (2148-56-3) + aniline (62-53-3) → (S)-tert-butyl (1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)carbamate (1615255-01-0)

Guidance literature:

t-Boc-L-valine; 2-chloro-6-aminobenzoic acid; With pyridine; diphenyl hydrogen phosphite; Inert atmosphere; Heating;

aniline; at 55 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2021.116312

Reference yield:

→ (S)-tert-butyl (1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)carbamate (1615255-01-0)

Guidance literature:

With pyridine; diphenyl phosphite; at 40 ℃; for 2h;

at 55 ℃; for 12h;

Reference yield: 36.0%

(S)-tert-butyl (1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)carbamate (1615255-01-0) → (S)-2-(1-amino-2-methylpropyl)-5-chloro-3-phenylquinazolin-4(3H)-one (1615256-54-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmc.2021.116312

upstream raw materials:

t-Boc-L-valine

2-chloro-6-aminobenzoic acid

aniline

Downstream raw materials:

(S)-2-(1-amino-2-methylpropyl)-5-chloro-3-phenylquinazolin-4(3H)-one

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