(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid methyl

Base Information

• Chemical Name: (2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid methyl
• CAS No.: 913722-90-4
• Molecular Formula: C₂₃H₂₅ClFNO₅
• Molecular Weight: 449.907
• Mol file: 913722-90-4.mol

Synonyms:(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid methyl

Chemical Property of (2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid methyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid methyl

There total 1 articles about (2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid methyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(2S)-3-(3-hydroxyphenyl)-2-isopropoxypropionic acid methyl (913722-84-6) + (2R)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropyl=methanesulfonate → (2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid methyl (913722-90-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 28h;

Reference yield: 90.0%

(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid methyl (913722-90-4) → (2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid (478926-45-3)

Guidance literature:

(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid methyl; With sodium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 3.5h;

With hydrogenchloride; In tert-butyl methyl ether; water; Product distribution / selectivity;

upstream raw materials:

(2S)-3-(3-hydroxyphenyl)-2-isopropoxypropionic acid methyl

Downstream raw materials:

(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid