3-[3-(2-methoxyphenylsulfonyloxy)-5-methylphenoxy]propionaldehyde

Base Information

• Chemical Name: 3-[3-(2-methoxyphenylsulfonyloxy)-5-methylphenoxy]propionaldehyde
• CAS No.: 197959-79-8
• Molecular Formula: C₁₇H₁₈O₆S
• Molecular Weight: 350.392
• Mol file: 197959-79-8.mol

Synonyms:3-[3-(2-methoxyphenylsulfonyloxy)-5-methylphenoxy]propionaldehyde

Chemical Property of 3-[3-(2-methoxyphenylsulfonyloxy)-5-methylphenoxy]propionaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[3-(2-methoxyphenylsulfonyloxy)-5-methylphenoxy]propionaldehyde

There total 6 articles about 3-[3-(2-methoxyphenylsulfonyloxy)-5-methylphenoxy]propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

3-[3-(2-methoxyphenylsulfonyloxy)-5-methylphenoxy]propanol (197959-78-7) → 3-[3-(2-methoxyphenylsulfonyloxy)-5-methylphenoxy]propionaldehyde (197959-79-8)

Guidance literature:

With pyridine-SO₃ complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield: 62.0%

citric acid (77-92-9,906507-37-7) + 3-[3-(2-methoxyphenylsulfonyloxy)-5-methylphenoxy]propanol (197959-78-7) → 3-[3-(2-methoxyphenylsulfonyloxy)-5-methylphenoxy]propionaldehyde (197959-79-8)

Guidance literature:

With dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

orcinol (504-15-4) → 3-[3-(2-methoxyphenylsulfonyloxy)-5-methylphenoxy]propionaldehyde (197959-79-8)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. NaHCO₃ / tetrahydrofuran; dibutyl ether

2: H₂ / 10 percent Pd/C / methanol / 760 Torr

3: PBu₃; ADDP

4: SO₃*pyridine; DMSO / CH₂Cl₂ / 0 - 20 °C

With pyridine-SO₃ complex; tributylphosphine; hydrogen; sodium hydrogencarbonate; dimethyl sulfoxide; 1,1'-azodicarbonyl-dipiperidine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; dibutyl ether; 1: Sulfonylation / 2: Hydrogenolysis / 3: Condensation / 4: Oxidation;

DOI:10.1016/S0960-894X(99)00632-0

upstream raw materials:

3-[3-(2-methoxyphenylsulfonyloxy)-5-methylphenoxy]propanol

orcinol

5-chloro-2-methoxybenzenesulfonyl chloride

3-(2-methoxyphenylsulfonyloxy)-5-methylphenol

Downstream raw materials:

2-[2-[3-(2-methoxyphenylsulfonyloxy)-5-methylphenoxy] ethyl-1-methylene]-hydrazinecarboxamide

3-[3-(2-methoxyphenylsulfonyloxy)-5-methylphenoxy]propionaldehyde thiosemicarbazone