Toluene-4-sulfonic acid 3-(6-chloro-hexyloxy)-2-hydroxy-propyl ester

Base Information

• Chemical Name: Toluene-4-sulfonic acid 3-(6-chloro-hexyloxy)-2-hydroxy-propyl ester
• CAS No.: 152467-59-9
• Molecular Formula: C₁₆H₂₅ClO₅S
• Molecular Weight: 364.89
• Mol file: 152467-59-9.mol

Synonyms:Toluene-4-sulfonic acid 3-(6-chloro-hexyloxy)-2-hydroxy-propyl ester

Chemical Property of Toluene-4-sulfonic acid 3-(6-chloro-hexyloxy)-2-hydroxy-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of Toluene-4-sulfonic acid 3-(6-chloro-hexyloxy)-2-hydroxy-propyl ester

There total 1 articles about Toluene-4-sulfonic acid 3-(6-chloro-hexyloxy)-2-hydroxy-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

6-chloro-1-hexanol (2009-83-8) + glycidyl p-toluenesulfonate (118712-54-2,6746-81-2) → Toluene-4-sulfonic acid 3-(6-chloro-hexyloxy)-2-hydroxy-propyl ester (152467-59-9)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane;

DOI:10.1016/S0040-4039(00)79333-6

Reference yield:

Toluene-4-sulfonic acid 3-(6-chloro-hexyloxy)-2-hydroxy-propyl ester (152467-59-9) → C46H78O6

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / K₂CO₃ / methanol

2: 60 percent / BF₃OEt₂ / CH₂Cl₂

3: 85 percent / NaH, n-Bu₄NI / tetrahydrofuran

4: 95 percent / KI / acetone

5: 1.) Mg, 2.) Ag / 1.) THF, 2.) THF, 60 deg C

With boron trifluoride diethyl etherate; silver; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; magnesium; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; acetone;

DOI:10.1016/S0040-4039(00)79333-6

Reference yield:

Toluene-4-sulfonic acid 3-(6-chloro-hexyloxy)-2-hydroxy-propyl ester (152467-59-9) → 1-Benzyloxy-3-(6-chloro-hexyloxy)-propan-2-ol (152467-61-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / K₂CO₃ / methanol

2: 60 percent / BF₃OEt₂ / CH₂Cl₂

With boron trifluoride diethyl etherate; potassium carbonate; In methanol; dichloromethane;

DOI:10.1016/S0040-4039(00)79333-6

upstream raw materials:

6-chloro-1-hexanol

glycidyl p-toluenesulfonate

Downstream raw materials:

1-Benzyloxy-3-(6-chloro-hexyloxy)-propan-2-ol

[3-(6-Chloro-hexyloxy)-2-heptyloxy-propoxymethyl]-benzene

[2-Heptyloxy-3-(6-iodo-hexyloxy)-propoxymethyl]-benzene