2-[(2-ethoxy-5(4-ethylpiperazine-1-sulphonyl)phenyl)]-7-ethoxycarbonyl-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

Base Information

Chemical Name:2-[(2-ethoxy-5(4-ethylpiperazine-1-sulphonyl)phenyl)]-7-ethoxycarbonyl-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one
CAS No.:1417529-69-1
Molecular Formula:C₂₃H₃₀N₆O₆S
Molecular Weight:518.594
Hs Code.:

Synonyms:2-[(2-ethoxy-5(4-ethylpiperazine-1-sulphonyl)phenyl)]-7-ethoxycarbonyl-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

Suppliers and Price of 2-[(2-ethoxy-5(4-ethylpiperazine-1-sulphonyl)phenyl)]-7-ethoxycarbonyl-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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TRC
2-[(2-Ethoxy-5(4-ethylpiperazine-1-sulphonyl)phenyl)]-7-ethoxycarbonyl-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one
10mg
$ 1320.00

TRC
2-[(2-Ethoxy-5(4-ethylpiperazine-1-sulphonyl)phenyl)]-7-ethoxycarbonyl-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one
1mg
$ 165.00

Total 7 raw suppliers

Chemical Property of 2-[(2-ethoxy-5(4-ethylpiperazine-1-sulphonyl)phenyl)]-7-ethoxycarbonyl-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

2-[(2-Ethoxy-5(4-ethylpiperazine-1-sulphonyl)phenyl)]-7-ethoxycarbonyl-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one ^*data from reagent suppliers

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Useful:

Uses 2-[(2-ethoxy-5(4-ethylpiperazine-1-sulphonyl)phenyl)]-7-ethoxycarbonyl-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one is a reagent in the preparation of imidazotriazinones which functions as substrates in the synthesis of phosphodiesterase 5 inhibitors.

Technology Process of 2-[(2-ethoxy-5(4-ethylpiperazine-1-sulphonyl)phenyl)]-7-ethoxycarbonyl-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

There total 5 articles about 2-[(2-ethoxy-5(4-ethylpiperazine-1-sulphonyl)phenyl)]-7-ethoxycarbonyl-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 5308-25-8
4-ethylpiperazine

: 1417529-68-0
C₁₇H₁₇ClN₄O₆S

: 1417529-69-1
2-[(2-ethoxy-5(4-ethylpiperazine-1-sulphonyl)phenyl)]-7-ethoxycarbonyl-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; for 18h;
DOI:10.1016/j.tet.2012.11.037

Reference yield:

: 1417529-65-7
N-{1-[3-(2-Ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}oxalamic acid ethyl ester

: 1417529-69-1
2-[(2-ethoxy-5(4-ethylpiperazine-1-sulphonyl)phenyl)]-7-ethoxycarbonyl-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / toluene / 2 h / Reflux

2: chlorosulfonic acid / 1.5 h / 20 °C

3: tetrahydrofuran / 18 h / 0 - 20 °C

With chlorosulfonic acid; trichlorophosphate; In tetrahydrofuran; toluene;
DOI:10.1016/j.tet.2012.11.037

Reference yield:

: 1417529-52-2
3-(2-ethoxyphenyl)-6-ethyl-4H-[1,2,4]triazin-5-one

: 1417529-69-1
2-[(2-ethoxy-5(4-ethylpiperazine-1-sulphonyl)phenyl)]-7-ethoxycarbonyl-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 14 h / Reflux; Inert atmosphere

2.1: ammonia / tetrahydrofuran / 20 °C

3.1: tertiary amine / dichloromethane / 0.08 h / Cooling

3.2: 1.17 h / 0 - 20 °C

4.1: trichlorophosphate / toluene / 2 h / Reflux

5.1: chlorosulfonic acid / 1.5 h / 20 °C

6.1: tetrahydrofuran / 18 h / 0 - 20 °C

With chlorosulfonic acid; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ammonia; trichlorophosphate; In tetrahydrofuran; tetrachloromethane; dichloromethane; toluene;
DOI:10.1016/j.tet.2012.11.037