(4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carboxylic acid (5-amino-pentyl)-amide

Base Information

• Chemical Name: (4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carboxylic acid (5-amino-pentyl)-amide
• CAS No.: 98612-57-8
• Molecular Formula: C₅₂H₇₈N₈O₈S₂
• Molecular Weight: 911.2
• Mol file: 98612-57-8.mol

Synonyms:(4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carboxylic acid (5-amino-pentyl)-amide

Chemical Property of (4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carboxylic acid (5-amino-pentyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carboxylic acid (5-amino-pentyl)-amide

There total 8 articles about (4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carboxylic acid (5-amino-pentyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-tert-butoxycarbonylamino-1-aminopentane (51644-96-3) + (4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carboxylic acid (98612-58-9) → (4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carboxylic acid (5-amino-pentyl)-amide (98612-57-8)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; Multistep reaction; 1.) DMF;

DOI:10.1021/jm00150a003

Reference yield:

5-tert-butoxycarbonylamino-1-aminopentane (51644-96-3) + (10R,13S,16S,19S,22R)-19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-16-isopropyl-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentaaza-spiro[5.19]pentacosane-10-carboxylic acid (98612-58-9) → (10R,13S,16S,19S,22R)-19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-16-isopropyl-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentaaza-spiro[5.19]pentacosane-10-carboxylic acid (5-amino-pentyl)-amide (98612-57-8)

Guidance literature:

With 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; Yield given. Multistep reaction; 1.) DMF, room temperature, 2.) 0 deg C;

DOI:10.1021/jm00122a017

Reference yield:

t-Boc-L-valine (13734-41-3) → (10R,13S,16S,19S,22R)-19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-16-isopropyl-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentaaza-spiro[5.19]pentacosane-10-carboxylic acid (5-amino-pentyl)-amide (98612-57-8)

Guidance literature:

Multi-step reaction with 3 steps

1: further educt: β-<(4-methylbenzyl)thio>-β,β-pentamethylenepropionic acid; solid phase method

2: potassium ferricyanide / H₂O

3: 1.) dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate, 2.) trifluoroacetic acid / 1.) DMF, room temperature, 2.) 0 deg C

With 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; potassium hexacyanoferrate(III); In water;

DOI:10.1021/jm00122a017

upstream raw materials:

5-tert-butoxycarbonylamino-1-aminopentane

(4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carboxylic acid

L-valine

L-phenylalanine

Downstream raw materials:

(10R,13S,16S,19S,22R)-19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-16-isopropyl-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentaaza-spiro[5.19]pentacosane-10-carboxylic acid (5-guanidino-pentyl)-amide