2-[(4-{2-[(4'-fluorobiphenyl-4-yl)oxy]-1-hydroxyethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid

Base Information

Chemical Name:2-[(4-{2-[(4'-fluorobiphenyl-4-yl)oxy]-1-hydroxyethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid
CAS No.:1228440-57-0
Molecular Formula:C₂₁H₂₀FNO₄S₂
Molecular Weight:433.525
Hs Code.:

Synonyms:2-[(4-{2-[(4'-fluorobiphenyl-4-yl)oxy]-1-hydroxyethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid

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Chemical Property of 2-[(4-{2-[(4'-fluorobiphenyl-4-yl)oxy]-1-hydroxyethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid

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Technology Process of 2-[(4-{2-[(4'-fluorobiphenyl-4-yl)oxy]-1-hydroxyethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid

There total 9 articles about 2-[(4-{2-[(4'-fluorobiphenyl-4-yl)oxy]-1-hydroxyethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 324-94-7
4'-fluoro-biphenyl-4-ol

: 1228440-57-0
2-[(4-{2-[(4'-fluorobiphenyl-4-yl)oxy]-1-hydroxyethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetra-(n-butyl)ammonium iodide; sodium hydroxide / toluene; water / 3 h / Reflux

2: ethanol; sodium tetrahydroborate / Cooling with ice

3: trifluoroacetic acid / dichloromethane / 20 °C

With sodium tetrahydroborate; ethanol; tetra-(n-butyl)ammonium iodide; trifluoroacetic acid; sodium hydroxide; In dichloromethane; water; toluene;

Reference yield:

: 1228440-59-2
2-[(4-{2-[(4'-fluorobiphenyl-4-yl)oxy]-1-hydroxyethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester

: 1228440-57-0
2-[(4-{2-[(4'-fluorobiphenyl-4-yl)oxy]-1-hydroxyethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 886527-12-4
2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazole-4-carboxylic acid

: 1228440-57-0
2-[(4-{2-[(4'-fluorobiphenyl-4-yl)oxy]-1-hydroxyethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2.1: tetrahydrofuran / 1 h / Cooling with ice

2.2: Cooling with ice

2.3: pH 3 / Cooling with ice

3.1: tetra-(n-butyl)ammonium iodide; sodium hydroxide / toluene; water / 3 h / Reflux

4.1: ethanol; sodium tetrahydroborate / Cooling with ice

5.1: trifluoroacetic acid / dichloromethane / 20 °C

With dmap; sodium tetrahydroborate; ethanol; tetra-(n-butyl)ammonium iodide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene;