(2S,3R,17R,18S)-2,18-diethyl-3,17-diphenyl-1-methyl-10-(p-tolylsulfonyl)-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

Base Information

• Chemical Name: (2S,3R,17R,18S)-2,18-diethyl-3,17-diphenyl-1-methyl-10-(p-tolylsulfonyl)-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane
• CAS No.: 150125-86-3
• Molecular Formula: C₃₆H₅₀N₂O₆S
• Molecular Weight: 638.869

Synonyms:(2S,3R,17R,18S)-2,18-diethyl-3,17-diphenyl-1-methyl-10-(p-tolylsulfonyl)-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

Chemical Property of (2S,3R,17R,18S)-2,18-diethyl-3,17-diphenyl-1-methyl-10-(p-tolylsulfonyl)-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R,17R,18S)-2,18-diethyl-3,17-diphenyl-1-methyl-10-(p-tolylsulfonyl)-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

There total 2 articles about (2S,3R,17R,18S)-2,18-diethyl-3,17-diphenyl-1-methyl-10-(p-tolylsulfonyl)-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-bis<2-(2-hydroxyethoxy)ethyl>-4-methylbenzenesulfonamide (72358-83-9,63413-83-2) → (2S,3R,17R,18S)-2,18-diethyl-3,17-diphenyl-1-methyl-10-(p-tolylsulfonyl)-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane (150125-86-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / triethylamine / CH₂Cl₂ / 48 h / 5 °C

2: 1.) NaH / 1.) THF, mineral oil, reflux, 2.) reflux

With sodium hydride; triethylamine; In dichloromethane;

DOI:10.1021/jo00068a029

Reference yield:

N,N-bis<2-<2-<(p-tolylsulfonyl)oxy>ethoxy>ethyl>-p-toluenesulfonamide (118187-55-6) + (1R,2S)-2-{[1-((R)-Hydroxy-phenyl-methyl)-propyl]-methyl-amino}-1-phenyl-butan-1-ol → (2S,3R,17R,18S)-2,18-diethyl-3,17-diphenyl-1-methyl-10-(p-tolylsulfonyl)-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane (150125-86-3)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) THF, mineral oil, reflux, 2.) reflux;

DOI:10.1021/jo00068a029

Reference yield: 57.0%

(2S,3R,17R,18S)-2,18-diethyl-3,17-diphenyl-1-methyl-10-(p-tolylsulfonyl)-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane (150125-86-3) → (2S,3R,17R,18S)-2,18-diethyl-3,17-diphenyl-1-methyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane (150125-98-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1021/jo00068a029

upstream raw materials:

N,N-bis<2-<2-<(p-tolylsulfonyl)oxy>ethoxy>ethyl>-p-toluenesulfonamide

N,N-bis<2-(2-hydroxyethoxy)ethyl>-4-methylbenzenesulfonamide

Downstream raw materials:

(2S,3R,17R,18S)-2,18-diethyl-3,17-diphenyl-1-methyl-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 150125-86-3 (2S,3R,17R,18S)-2,18-diethyl-3,17-diphenyl-1-methyl-10-(p-tolylsulfonyl)-1,10-diaza-4,7,13,16-tetraoxacyclooctadecane

Send

Send

Metric Ton KG G Pound L ML

Send

Send