Technology Process of (2R,3S)-3-[(S)-1-(tert-butyldimethylsiloxy)ethyl]-2,3-(isopropylidenedioxy)-4-oxo-4-phenylbutanal
There total 7 articles about (2R,3S)-3-[(S)-1-(tert-butyldimethylsiloxy)ethyl]-2,3-(isopropylidenedioxy)-4-oxo-4-phenylbutanal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere
2: lithium chloride / tetrahydrofuran; dibutyl ether / 0.17 h / -10 °C / Inert atmosphere
3: toluene-4-sulfonic acid / 1.5 h / 20 °C / Inert atmosphere
With
toluene-4-sulfonic acid; triethylamine; lithium chloride;
In
tetrahydrofuran; dichloromethane; dibutyl ether;
DOI:10.1016/j.tet.2013.05.091
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
1.2: 0.5 h / -78 °C / Inert atmosphere
2.1: trimethyl(benzyl)ammonium fluoride / tetrahydrofuran / 2.3 h / -78 - -10 °C / Molecular sieve; Inert atmosphere
3.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere
4.1: lithium chloride / tetrahydrofuran; dibutyl ether / 0.17 h / -10 °C / Inert atmosphere
5.1: toluene-4-sulfonic acid / 1.5 h / 20 °C / Inert atmosphere
With
trimethyl(benzyl)ammonium fluoride; toluene-4-sulfonic acid; triethylamine; lithium chloride; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; dibutyl ether;
DOI:10.1016/j.tet.2013.05.091
