methyl 4-[4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-amino}ethyl)phenoxy]benzoate

Base Information

• Chemical Name: methyl 4-[4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-amino}ethyl)phenoxy]benzoate
• CAS No.: 643091-05-8
• Molecular Formula: C₂₉H₃₂ClNO₆
• Molecular Weight: 526.029
• Mol file: 643091-05-8.mol

Synonyms:methyl 4-[4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-amino}ethyl)phenoxy]benzoate

Chemical Property of methyl 4-[4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-amino}ethyl)phenoxy]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-[4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-amino}ethyl)phenoxy]benzoate

There total 1 articles about methyl 4-[4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-amino}ethyl)phenoxy]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

tert-butyl 2-(4-hydroxyphenyl)ethyl[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]carbamate (150014-08-7) + 4-methoxycarbonylphenylboronic acid (99768-12-4) → methyl 4-[4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-amino}ethyl)phenoxy]benzoate (643091-05-8)

Guidance literature:

With copper diacetate; 4 A molecular sieve; triethylamine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/jm701324c

Reference yield:

methyl 4-[4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-amino}ethyl)phenoxy]benzoate (643091-05-8) → 4-[4-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-phenoxy]benzoic acid hydrochloride (643091-06-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol;

Reference yield:

methyl 4-[4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-amino}ethyl)phenoxy]benzoate (643091-05-8) → C28H30ClNO6

Guidance literature:

With sodium hydroxide; In ethanol; at 40 ℃;

DOI:10.1021/jm701324c

upstream raw materials:

tert-butyl 2-(4-hydroxyphenyl)ethyl[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]carbamate

4-methoxycarbonylphenylboronic acid

Downstream raw materials:

4-[4-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-phenoxy]benzoic acid hydrochloride