C₁₈H₁₆O₃S

Base Information

• Chemical Name: C₁₈H₁₆O₃S
• CAS No.: 1309773-48-5
• Molecular Formula: C₁₈H₁₆O₃S
• Molecular Weight: 312.389
• Mol file: 1309773-48-5.mol

Synonyms:C₁₈H₁₆O₃S

Chemical Property of C₁₈H₁₆O₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₆O₃S

There total 5 articles about C₁₈H₁₆O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

C18H18O4S (1309773-45-2) → C18H16O3S (1309773-48-5)

Guidance literature:

C₁₈H₁₈O₄S; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

With toluene-4-sulfonic acid; In toluene; for 16h; Reflux;

DOI:10.1016/j.tetlet.2011.03.120

Reference yield:

sodium benzenesulfonate (873-55-2) → C18H16O3S (1309773-48-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 20 °C

2.1: methanol; sodium hydrogencarbonate / 20 °C

3.1: pyridine / dichloromethane / 0 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C / Inert atmosphere

4.2: 16 h / Reflux

With pyridine; methanol; sodium hydrogencarbonate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2011.03.120

Reference yield:

C15H14O4S (1309773-28-1) → C18H16O3S (1309773-48-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol; sodium hydrogencarbonate / 20 °C

2.1: pyridine / dichloromethane / 0 - 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C / Inert atmosphere

3.2: 16 h / Reflux

With pyridine; methanol; sodium hydrogencarbonate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetlet.2011.03.120

upstream raw materials:

C₁₅H₁₄O₄S

2-(phenylsulfonylmethyl)phenol

C₁₈H₁₈O₄S

o-chloromethylphenyl acetate