N-{5-[2-amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-2-cyanophenyl}-2-(4-trifluoromethylphenyl)acetamide

Base Information

Chemical Name:N-{5-[2-amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-2-cyanophenyl}-2-(4-trifluoromethylphenyl)acetamide
CAS No.:1596334-85-8
Molecular Formula:C₂₇H₂₃F₃N₆O₃
Molecular Weight:536.513
Hs Code.:

Synonyms:N-{5-[2-amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-2-cyanophenyl}-2-(4-trifluoromethylphenyl)acetamide

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Chemical Property of N-{5-[2-amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-2-cyanophenyl}-2-(4-trifluoromethylphenyl)acetamide

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Technology Process of N-{5-[2-amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-2-cyanophenyl}-2-(4-trifluoromethylphenyl)acetamide

There total 13 articles about N-{5-[2-amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-2-cyanophenyl}-2-(4-trifluoromethylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1596336-68-3
N-(5-{2-amino-7-[2-(tert-butyldimethylsilanyloxy)-1,1-dimethylethyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl}-2-cyanophenyl)-2-(4-trifluoromethylphenyl)acetamide

: 1596334-85-8
N-{5-[2-amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-2-cyanophenyl}-2-(4-trifluoromethylphenyl)acetamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield:

: 1596336-81-0
4-[7-[1,1-dimethyl-2-(tetrahydropyran-2-yloxy)ethyl]-2-(4-methoxybenzylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-2-(4-methoxybenzylamino)benzonitrile

: 1596334-85-8
N-{5-[2-amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-2-cyanophenyl}-2-(4-trifluoromethylphenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / 16 h / 20 °C

2: 2,6-dimethylpyridine / dichloromethane / 16 h / 0 - 20 °C

3: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / tetrahydrofuran; ethyl acetate / 18 h / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 - 20 °C

With 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

: 1596337-11-9
4-{2-chloro-7-[1,1-dimethyl-2-(tetrahydropyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl}-2-fluorobenzonitrile

: 1596334-85-8
N-{5-[2-amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-2-cyanophenyl}-2-(4-trifluoromethylphenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: dimethyl sulfoxide / 16 h / 100 °C

2: trifluoroacetic acid / 16 h / 20 °C

3: 2,6-dimethylpyridine / dichloromethane / 16 h / 0 - 20 °C

4: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / tetrahydrofuran; ethyl acetate / 18 h / 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 - 20 °C

With 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; ethyl acetate;