(3R,4S)-N⁽²⁾,3-dimethyl-4-phenyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(3R,4S)-N⁽²⁾,3-dimethyl-4-phenyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:1242105-66-3
Molecular Formula:C₁₈H₂₁NO
Molecular Weight:267.371
Hs Code.:

(3R,4S)-N<sup>(2)</sup>,3-dimethyl-4-phenyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline

Synonyms:(3R,4S)-N⁽²⁾,3-dimethyl-4-phenyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S)-N⁽²⁾,3-dimethyl-4-phenyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (3R,4S)-N⁽²⁾,3-dimethyl-4-phenyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline

There total 2 articles about (3R,4S)-N⁽²⁾,3-dimethyl-4-phenyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1242105-58-3
(1R,2R)-1-phenyl-2-[N-methyl-N-(3'-methoxybenzyl)amino]propan-1-ol

: 1242105-69-6
(3R,4R)-N⁽²⁾,3-dimethyl-4-phenyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline

: 1242105-66-3
(3R,4S)-N⁽²⁾,3-dimethyl-4-phenyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sulfuric acid; trifluoroacetic acid; In dichloromethane; at 40 ℃; for 1.75h; optical yield given as %de; diastereoselective reaction;
DOI:10.1002/asia.200900470

Reference yield:

: 130549-59-6
(4R,5R)-2-cyclohexyl-N⁽³⁾,4-dimethyl-5-phenyloxazolidine

: 591-31-1
3-methoxy-benzaldehyde

: 1242105-66-3
(3R,4S)-N⁽²⁾,3-dimethyl-4-phenyl-7-methoxy-1,2,3,4-tetrahydroisoquinoline

: 1242105-80-1
(3R,4S)-N⁽²⁾,3-dimethyl-4-phenyl-5-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: (4R,5R)-2-cyclohexyl-N⁽³⁾,4-dimethyl-5-phenyloxazolidine; With chromium⁽⁰⁾ hexacarbonyl; In tetrahydrofuran; dibutyl ether; for 48h; Inert atmosphere; Reflux;

With hydrogenchloride; water; toluene-4-sulfonic acid; In tetrahydrofuran; for 15h; Reflux;

3-methoxy-benzaldehyde; diastereoselective reaction; Further stages;
DOI:10.1002/asia.200900470