6-(3-ethylureido)-4-(phenylamino)-N-(2-(trifluoromethyl)phenyl)nicotinamide

Base Information

Chemical Name:6-(3-ethylureido)-4-(phenylamino)-N-(2-(trifluoromethyl)phenyl)nicotinamide
CAS No.:1445151-24-5
Molecular Formula:C₂₂H₂₀F₃N₅O₂
Molecular Weight:443.428
Hs Code.:

Synonyms:6-(3-ethylureido)-4-(phenylamino)-N-(2-(trifluoromethyl)phenyl)nicotinamide

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Chemical Property of 6-(3-ethylureido)-4-(phenylamino)-N-(2-(trifluoromethyl)phenyl)nicotinamide

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Technology Process of 6-(3-ethylureido)-4-(phenylamino)-N-(2-(trifluoromethyl)phenyl)nicotinamide

There total 8 articles about 6-(3-ethylureido)-4-(phenylamino)-N-(2-(trifluoromethyl)phenyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1445153-82-1
6-(3-ethylureido)-4-(phenylamino)nicotinic acid

: 88-17-5
2-(trifluoromethyl)benzenamine

: 1445151-24-5
6-(3-ethylureido)-4-(phenylamino)-N-(2-(trifluoromethyl)phenyl)nicotinamide

Guidance literature:: 6-(3-ethylureido)-4-(phenylamino)nicotinic acid; With 2,6-dimethylpyridine; methanesulfonyl chloride; In N,N-dimethyl acetamide; at 0 ℃; for 0.5h;

2-(trifluoromethyl)benzenamine; In N,N-dimethyl acetamide; at 20 - 50 ℃; for 4.16667h;

Reference yield:

: 1012878-94-2
ethyl 6-chloro-4-(phenylamino)nicotinate

: 1445151-24-5
6-(3-ethylureido)-4-(phenylamino)-N-(2-(trifluoromethyl)phenyl)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16.5 h / 80 °C / Inert atmosphere

2.1: water; sodium hydroxide / 48 h / 75 °C

3.1: methanesulfonyl chloride; 2,6-dimethylpyridine / N,N-dimethyl acetamide / 0.5 h / 0 °C

3.2: 4.17 h / 20 - 50 °C

With 2,6-dimethylpyridine; water; palladium diacetate; caesium carbonate; methanesulfonyl chloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; In 1,4-dioxane; N,N-dimethyl acetamide;

Reference yield:

: 105-50-0
diethyl 1,3-acetonedicarboxylate

: 1445151-24-5
6-(3-ethylureido)-4-(phenylamino)-N-(2-(trifluoromethyl)phenyl)nicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic anhydride; ammonia / water / 20 h / 0 - 120 °C / Inert atmosphere

2.1: trichlorophosphate / 2.5 h / 110 °C

3.1: hydrogenchloride / ethanol / 80 °C

4.1: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16.5 h / 80 °C / Inert atmosphere

5.1: water; sodium hydroxide / 48 h / 75 °C

6.1: methanesulfonyl chloride; 2,6-dimethylpyridine / N,N-dimethyl acetamide / 0.5 h / 0 °C

6.2: 4.17 h / 20 - 50 °C

With 2,6-dimethylpyridine; hydrogenchloride; ammonia; water; palladium diacetate; acetic anhydride; caesium carbonate; methanesulfonyl chloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; trichlorophosphate; In 1,4-dioxane; ethanol; N,N-dimethyl acetamide; water;