4-(4-aminophenyl)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)butyramide

Base Information

Chemical Name:4-(4-aminophenyl)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)butyramide
CAS No.:911297-07-9
Molecular Formula:C₁₈H₁₈F₃N₃O₄
Molecular Weight:397.354
Hs Code.:

Synonyms:4-(4-aminophenyl)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)butyramide

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Chemical Property of 4-(4-aminophenyl)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)butyramide

Chemical Property:

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Technology Process of 4-(4-aminophenyl)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)butyramide

There total 6 articles about 4-(4-aminophenyl)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-hydroxy-2-methyl-4-(4-nitro-phenyl)-butyronitrile

: 911297-07-9
4-(4-aminophenyl)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 805 mg / hydrochloric acid; acetic acid / 0.5 h / Heating

2: 100 percent / H₂ / Pd-C / methanol / 3 h / 1551.44 Torr

3: thionyl chloride; DMF / tetrahydrofuran / 1 h / 20 °C

4: 246 mg / triethylamine / tetrahydrofuran / 3 h / 20 °C

With hydrogenchloride; thionyl chloride; hydrogen; acetic acid; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2006.06.019

Reference yield:

: 911297-05-7
2-hydroxy-2-methyl-4-(4-nitrophenyl)butyric acid

: 911297-07-9
4-(4-aminophenyl)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pd-C / methanol / 3 h / 1551.44 Torr

2: thionyl chloride; DMF / tetrahydrofuran / 1 h / 20 °C

3: 246 mg / triethylamine / tetrahydrofuran / 3 h / 20 °C

With thionyl chloride; hydrogen; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2006.06.019

Reference yield:

: 30780-19-9
4-(4-nitrophenyl)butan-2-one

: 911297-07-9
4-(4-aminophenyl)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: ZnI₂ / CH₂Cl₂ / 1 h / 20 °C

2: 805 mg / hydrochloric acid; acetic acid / 0.5 h / Heating

3: 100 percent / H₂ / Pd-C / methanol / 3 h / 1551.44 Torr

4: thionyl chloride; DMF / tetrahydrofuran / 1 h / 20 °C

5: 246 mg / triethylamine / tetrahydrofuran / 3 h / 20 °C

With hydrogenchloride; thionyl chloride; hydrogen; acetic acid; triethylamine; N,N-dimethyl-formamide; zinc(II) iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmc.2006.06.019