Technology Process of (CH3)2(C6H5)4C5H2O4POCH2C6H4C6H4CH2CH(C3H3NOC6H5)2
There total 5 articles about (CH3)2(C6H5)4C5H2O4POCH2C6H4C6H4CH2CH(C3H3NOC6H5)2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dmap; triethylamine;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
DOI:10.1021/ja049873+
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 94 percent / Pd(PPh3)4; aq. Cs2CO3 / dimethylformamide / 16 h / 100 °C
2.1: 84 percent / triphenylphosphine; carbon tetrabromide / CH2Cl2 / 6 h / 0 - 20 °C
3.1: LDA; DMPU; TMEDA / tetrahydrofuran; hexane / 2 h / -78 °C
3.2: 73 percent / DMPU / tetrahydrofuran / 12 h / 20 °C
4.1: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 16 h / 20 °C
5.1: 81 percent / Et3N; DMAP / tetrahydrofuran / 24 h / 20 °C
With
dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tetrakis(triphenylphosphine) palladium(0); carbon tetrabromide; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; caesium carbonate; triethylamine; triphenylphosphine; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
1.1: Suzuki coupling;
DOI:10.1021/ja049873+
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: LDA; DMPU; TMEDA / tetrahydrofuran; hexane / 2 h / -78 °C
1.2: 73 percent / DMPU / tetrahydrofuran / 12 h / 20 °C
2.1: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 16 h / 20 °C
3.1: 81 percent / Et3N; DMAP / tetrahydrofuran / 24 h / 20 °C
With
dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
DOI:10.1021/ja049873+