(CH₃)2(C₆H₅)4C₅H₂O₄POCH₂C₆H₄C₆H₄CH₂CH(C₃H₃NOC₆H₅)2

Base Information

• Chemical Name: (CH₃)2(C₆H₅)4C₅H₂O₄POCH₂C₆H₄C₆H₄CH₂CH(C₃H₃NOC₆H₅)2
• CAS No.: 691407-76-8
• Molecular Formula: C₆₄H₅₇N₂O₇P
• Molecular Weight: 997.14
• Mol file: 691407-76-8.mol

Synonyms:(CH₃)2(C₆H₅)4C₅H₂O₄POCH₂C₆H₄C₆H₄CH₂CH(C₃H₃NOC₆H₅)2

Chemical Property of (CH₃)2(C₆H₅)4C₅H₂O₄POCH₂C₆H₄C₆H₄CH₂CH(C₃H₃NOC₆H₅)2

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (CH₃)2(C₆H₅)4C₅H₂O₄POCH₂C₆H₄C₆H₄CH₂CH(C₃H₃NOC₆H₅)2

There total 5 articles about (CH₃)2(C₆H₅)4C₅H₂O₄POCH₂C₆H₄C₆H₄CH₂CH(C₃H₃NOC₆H₅)2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(3aR,8aR)-6-chloro-2,2-dimethyl-4,4,8,8-tetraphenyltetrahydro[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine (299917-90-1) + {3'-[2,2-Bis-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-ethyl]-biphenyl-2-yl}-methanol (691407-74-6) → (CH3)2(C6H5)4C5H2O4POCH2C6H4C6H4CH2CH(C3H3NOC6H5)2 (691407-76-8)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1021/ja049873+

Reference yield:

(2-Bromo-benzyloxy)-tert-butyl-diphenyl-silane (132286-87-4) → (CH3)2(C6H5)4C5H2O4POCH2C6H4C6H4CH2CH(C3H3NOC6H5)2 (691407-76-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 94 percent / Pd(PPh₃)4; aq. Cs₂CO₃ / dimethylformamide / 16 h / 100 °C

2.1: 84 percent / triphenylphosphine; carbon tetrabromide / CH₂Cl₂ / 6 h / 0 - 20 °C

3.1: LDA; DMPU; TMEDA / tetrahydrofuran; hexane / 2 h / -78 °C

3.2: 73 percent / DMPU / tetrahydrofuran / 12 h / 20 °C

4.1: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 16 h / 20 °C

5.1: 81 percent / Et₃N; DMAP / tetrahydrofuran / 24 h / 20 °C

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; caesium carbonate; triethylamine; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 1.1: Suzuki coupling;

DOI:10.1021/ja049873+

Reference yield:

(3'-bromomethyl-biphenyl-2-ylmethoxy)-tert-butyl-diphenyl-silane (691407-72-4) → (CH3)2(C6H5)4C5H2O4POCH2C6H4C6H4CH2CH(C3H3NOC6H5)2 (691407-76-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: LDA; DMPU; TMEDA / tetrahydrofuran; hexane / 2 h / -78 °C

1.2: 73 percent / DMPU / tetrahydrofuran / 12 h / 20 °C

2.1: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 16 h / 20 °C

3.1: 81 percent / Et₃N; DMAP / tetrahydrofuran / 24 h / 20 °C

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane;

DOI:10.1021/ja049873+

upstream raw materials:

(3aR,8aR)-6-chloro-2,2-dimethyl-4,4,8,8-tetraphenyltetrahydro[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine

{3'-[2,2-Bis-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-ethyl]-biphenyl-2-yl}-methanol

(2-Bromo-benzyloxy)-tert-butyl-diphenyl-silane

[2'-(tert-butyl-diphenyl-silanyloxymethyl)-biphenyl-3-yl]-methanol