Fmoc-D-Phe-Gly-O-tBu

Base Information

Chemical Name:Fmoc-D-Phe-Gly-O-tBu
CAS No.:1313886-77-9
Molecular Formula:C₃₀H₃₂N₂O₅
Molecular Weight:500.594
Hs Code.:

Synonyms:Fmoc-D-Phe-Gly-O-tBu

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Fmoc-D-Phe-Gly-O-tBu

Chemical Property:

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Technology Process of Fmoc-D-Phe-Gly-O-tBu

There total 1 articles about Fmoc-D-Phe-Gly-O-tBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 27532-96-3
glycine tert-butyl ester hydrochloride

: 86123-10-6
Fmoc-D-Phe-OH

: 1313886-77-9
Fmoc-D-Phe-Gly-O-tBu

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2.5h; Inert atmosphere;
DOI:10.1021/jo200497j

Reference yield:

: 1313886-77-9
Fmoc-D-Phe-Gly-O-tBu

: Fmoc-D-thionoPhe-Gly-O-tBu

Guidance literature:: With Lawessons reagent; In toluene; for 2h; Reflux; Inert atmosphere;
DOI:10.1021/jo200497j

Reference yield:

: 1313886-77-9
Fmoc-D-Phe-Gly-O-tBu

: 1313886-78-0
Fmoc-D-thionoPhe-Gly-OH

Guidance literature:: Multi-step reaction with 2 steps

1: Lawessons reagent / toluene / 2 h / Reflux; Inert atmosphere

2: triethylsilane; trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With Lawessons reagent; triethylsilane; trifluoroacetic acid; In dichloromethane; toluene;
DOI:10.1021/jo200497j