triisopropylsilyl [2R,3R,(S)S]-2-methyl-4-[2-(p-tolylsulfinyl)phenyl]-3-(triisopropylsilyloxy)butanoate

Base Information

Chemical Name:triisopropylsilyl [2R,3R,(S)S]-2-methyl-4-[2-(p-tolylsulfinyl)phenyl]-3-(triisopropylsilyloxy)butanoate
CAS No.:919764-62-8
Molecular Formula:C₃₆H₆₀O₄SSi₂
Molecular Weight:645.107
Hs Code.:

Synonyms:triisopropylsilyl [2R,3R,(S)S]-2-methyl-4-[2-(p-tolylsulfinyl)phenyl]-3-(triisopropylsilyloxy)butanoate

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Chemical Property of triisopropylsilyl [2R,3R,(S)S]-2-methyl-4-[2-(p-tolylsulfinyl)phenyl]-3-(triisopropylsilyloxy)butanoate

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Technology Process of triisopropylsilyl [2R,3R,(S)S]-2-methyl-4-[2-(p-tolylsulfinyl)phenyl]-3-(triisopropylsilyloxy)butanoate

There total 1 articles about triisopropylsilyl [2R,3R,(S)S]-2-methyl-4-[2-(p-tolylsulfinyl)phenyl]-3-(triisopropylsilyloxy)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 919764-61-7
[2R,3R,(S)S]-3-hydroxy-2-methyl-4-[2-(p-tolylsulfinyl)phenyl]butanoic acid

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 919764-62-8
triisopropylsilyl [2R,3R,(S)S]-2-methyl-4-[2-(p-tolylsulfinyl)phenyl]-3-(triisopropylsilyloxy)butanoate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1016/j.tet.2006.10.010

Reference yield: 94.0%

: 919764-62-8
triisopropylsilyl [2R,3R,(S)S]-2-methyl-4-[2-(p-tolylsulfinyl)phenyl]-3-(triisopropylsilyloxy)butanoate

: triisopropylsilyl [2R,3R]-2-methyl-4-phenyl-3-(triisopropylsilyloxy)butanoate

Guidance literature:: With nickel; In ethanol; at 20 ℃; for 14h;
DOI:10.1016/j.tet.2006.10.010

Reference yield:

: 919764-62-8
triisopropylsilyl [2R,3R,(S)S]-2-methyl-4-[2-(p-tolylsulfinyl)phenyl]-3-(triisopropylsilyloxy)butanoate

: (2R,3R)-3-hydroxy-2-methyl-4-phenylbutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / activated Raney nickel / ethanol / 14 h / 20 °C

2: 68 percent / hydrogen fluoride; pyridine / tetrahydrofuran / 17 h / 0 - 20 °C

With pyridine; hydrogen fluoride; nickel; In tetrahydrofuran; ethanol;
DOI:10.1016/j.tet.2006.10.010