tert-butyl 1-(2-pyridinyl)-3-[4-(3'-dimethylamino)biphenyl]-5-pyrazolyl carbonate

Base Information

Chemical Name:tert-butyl 1-(2-pyridinyl)-3-[4-(3'-dimethylamino)biphenyl]-5-pyrazolyl carbonate
CAS No.:1270084-11-1
Molecular Formula:C₂₇H₂₈N₄O₃
Molecular Weight:456.544
Hs Code.:

Synonyms:tert-butyl 1-(2-pyridinyl)-3-[4-(3'-dimethylamino)biphenyl]-5-pyrazolyl carbonate

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Chemical Property of tert-butyl 1-(2-pyridinyl)-3-[4-(3'-dimethylamino)biphenyl]-5-pyrazolyl carbonate

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Technology Process of tert-butyl 1-(2-pyridinyl)-3-[4-(3'-dimethylamino)biphenyl]-5-pyrazolyl carbonate

There total 5 articles about tert-butyl 1-(2-pyridinyl)-3-[4-(3'-dimethylamino)biphenyl]-5-pyrazolyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 178752-79-9
3-(N,N-dimethylamino)phenylboronic acid

: 1270083-94-7
3-(4-bromophenyl)-1-(pyridin-2-yl)-1H-pyrazol-5-yl t-butyl carbonate

: 1270084-11-1
tert-butyl 1-(2-pyridinyl)-3-[4-(3'-dimethylamino)biphenyl]-5-pyrazolyl carbonate

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In 1,4-dioxane; at 100 ℃; for 1h;
DOI:10.1055/s-0030-1260018

Reference yield: 80.5%

: 1270084-11-1
tert-butyl 1-(2-pyridinyl)-3-[4-(3'-dimethylamino)biphenyl]-5-pyrazolyl carbonate

Guidance literature:

Reference yield:

: 1270084-03-1
3-(4-bromophenyl)-1-(pyridin-2-yl)-1H-pyrazol-5-yl acetate

: 1270084-11-1
tert-butyl 1-(2-pyridinyl)-3-[4-(3'-dimethylamino)biphenyl]-5-pyrazolyl carbonate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane / 30 h / 85 - 100 °C

2: dmap / dichloromethane

3: potassium phosphate; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1 h / 100 °C

With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; 3: Suzuki-Miyaura cross-coupling;
DOI:10.1055/s-0030-1260018