2(1H)-Pyrimidinone,4-amino-1-(2,3-dideoxy-2-methyl-bta-D-threo-pentofuranosyl)-(9CI)

Base Information

Chemical Name:2(1H)-Pyrimidinone,4-amino-1-(2,3-dideoxy-2-methyl-bta-D-threo-pentofuranosyl)-(9CI)
CAS No.:792160-40-8
Molecular Formula:C₁₀H₁₅N₃O₃
Molecular Weight:225.247
Hs Code.:
Mol file:792160-40-8.mol

Synonyms:2(1H)-Pyrimidinone,4-amino-1-(2,3-dideoxy-2-methyl-bta-D-threo-pentofuranosyl)-(9CI)

Suppliers and Price of 2(1H)-Pyrimidinone,4-amino-1-(2,3-dideoxy-2-methyl-bta-D-threo-pentofuranosyl)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2(1H)-Pyrimidinone,4-amino-1-(2,3-dideoxy-2-methyl-bta-D-threo-pentofuranosyl)-(9CI)

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2(1H)-Pyrimidinone,4-amino-1-(2,3-dideoxy-2-methyl-bta-D-threo-pentofuranosyl)-(9CI)

There total 14 articles about 2(1H)-Pyrimidinone,4-amino-1-(2,3-dideoxy-2-methyl-bta-D-threo-pentofuranosyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1027366-46-6
N-[1-((2R,3R,5S)-5-Hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide

: 792160-40-8
1-(2,3-dideoxy-2-C-methyl-β-D-erythro-pentofuranosyl)cytosine

Guidance literature:: With ammonia; In methanol; for 18h;
DOI:10.1080/07328319608002379

Reference yield: 80.0%

: 1027565-86-1
N-[1-((2S,3R,5S)-5-Hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide

: 792160-40-8
1-(2,3-dideoxy-2-C-methyl-α-D-erythro-pentofuranosyl)cytosine

Guidance literature:: With ammonia; In methanol; for 18h;
DOI:10.1080/07328319608002379

Reference yield:

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 792160-40-8
1-(2,3-dideoxy-2-C-methyl-β-D-erythro-pentofuranosyl)cytosine

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

2: 58.7 percent / LDA / tetrahydrofuran / 2 h / -78 °C

3: 74.6 percent / DIBALH / CH₂Cl₂ / 2 h / -78 °C

4: 86.6 percent / Py, DMAP / CH₂Cl₂ / 2 h / 0 °C

5: 40.9 percent / trimethylsilyl trifluoromethane sulfonate / 1,2-dichloro-ethane / 0.58 h / Ambient temperature

6: TBAF / tetrahydrofuran / 3 h / Ambient temperature

7: 84 percent / NH₃ / methanol / 18 h

With pyridine; 1H-imidazole; dmap; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; ammonia; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1080/07328319608002379