Technology Process of 5'-O-(dimethoxytrityl)-2'-deoxy-2'-C-β-methyl-N4-benzoylcytidine
There total 11 articles about 5'-O-(dimethoxytrityl)-2'-deoxy-2'-C-β-methyl-N4-benzoylcytidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 100 percent / ammonia gas / methanol / 48 h / 0 - 4 °C
2: 65 percent / imidazole / dimethylformamide / 2 h / 20 °C
3: DMAP / acetonitrile / 1 h / 20 °C
4: 0.502 g / 2,2'-azobisisobutyronitrile; tributyltin hydride / toluene / 2 h / Heating
5: triethylamine; DMAP / acetonitrile / 53 h / 20 °C
6: 0.337 g / ammonium hydroxide / H2O; acetonitrile / 3 h / 20 °C
7: 93 percent / DMAP / CH2Cl2 / 1 h / 20 °C
8: 100 percent / triethylamine trihydrofluoride / tetrahydrofuran / 4 h / 20 °C
9: 100 percent / pyridine / 20 °C
With
pyridine; 1H-imidazole; dmap; ammonium hydroxide; 2,2'-azobis(isobutyronitrile); triethylamine trihydrofluoride; ammonia; tri-n-butyl-tin hydride; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jo034263y
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triethylamine; DMAP / acetonitrile / 53 h / 20 °C
2: 0.337 g / ammonium hydroxide / H2O; acetonitrile / 3 h / 20 °C
3: 93 percent / DMAP / CH2Cl2 / 1 h / 20 °C
4: 100 percent / triethylamine trihydrofluoride / tetrahydrofuran / 4 h / 20 °C
5: 100 percent / pyridine / 20 °C
With
pyridine; dmap; ammonium hydroxide; triethylamine trihydrofluoride; triethylamine;
In
tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jo034263y