Propanamide, N-[[3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinyl]methyl]- (9CI)

Base Information

Chemical Name:Propanamide, N-[[3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinyl]methyl]- (9CI)
CAS No.:792153-41-4
Molecular Formula:C₁₁H₁₆N₂O₃
Molecular Weight:224.26
Hs Code.:
Mol file:792153-41-4.mol

Synonyms:Propanamide, N-[[3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinyl]methyl]- (9CI)

Suppliers and Price of Propanamide, N-[[3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinyl]methyl]- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Propanamide, N-[[3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinyl]methyl]- (9CI)

Chemical Property:

PSA：82.45000
LogP:1.00500

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Propanamide, N-[[3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinyl]methyl]- (9CI)

There total 5 articles about Propanamide, N-[[3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinyl]methyl]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128175-41-7
4-(N-acryloylaminomethyl)-3-hydroxy-5-hydroxymethyl-2-methylpyridine hydrochloride

: 792153-41-4
3-hydroxy-5-hydroxymethyl-2-methyl-4-(N-propionylaminomethyl)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: CF₃SO₃H-H₂O (1:5) / acetonitrile / 0.67 h

2: 65 percent / HCl / ethanol

3: 1.) NiCl₂*6H₂O 2.) NaBH₄ / 1.) MeOH-THF (1:9) 2.) 0 deg C, 15 min

With hydrogenchloride; sodium tetrahydroborate; trifluorormethanesulfonic acid; nickel dichloride; In ethanol; acetonitrile;
DOI:10.1248/cpb.38.19

Reference yield:

: 54522-06-4
4-(N-acryloylaminomethyl)-3-hydroxy-5-hydroxymethyl-2-methylpyridine

: 792153-41-4
3-hydroxy-5-hydroxymethyl-2-methyl-4-(N-propionylaminomethyl)pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 52 percent / HCl(g) / ethanol

2: CF₃SO₃H-H₂O (1:5) / acetonitrile / 0.67 h

3: 65 percent / HCl / ethanol

4: 1.) NiCl₂*6H₂O 2.) NaBH₄ / 1.) MeOH-THF (1:9) 2.) 0 deg C, 15 min

With hydrogenchloride; sodium tetrahydroborate; trifluorormethanesulfonic acid; nickel dichloride; In ethanol; acetonitrile;
DOI:10.1248/cpb.38.19

Reference yield:

: 128175-47-3
6-hydroxymethyl-9-methyl-2-phenylselenomethyl-2,3,4,5-tetrahydropyrido<4,3-f><1,4>oxazepin-3-one

: 792153-41-4
3-hydroxy-5-hydroxymethyl-2-methyl-4-(N-propionylaminomethyl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / HCl / ethanol

2: 1.) NiCl₂*6H₂O 2.) NaBH₄ / 1.) MeOH-THF (1:9) 2.) 0 deg C, 15 min

With hydrogenchloride; sodium tetrahydroborate; nickel dichloride; In ethanol;
DOI:10.1248/cpb.38.19