N-(4-methoxyphenyl)piperazineacetohydrazide

Base Information

• Chemical Name: N-(4-methoxyphenyl)piperazineacetohydrazide
• CAS No.: 68104-78-9
• Molecular Formula: C₁₃H₂₀N₄O₂
• Molecular Weight: 264.327
• Mol file: 68104-78-9.mol

Synonyms:N-(4-methoxyphenyl)piperazineacetohydrazide

Chemical Property of N-(4-methoxyphenyl)piperazineacetohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-methoxyphenyl)piperazineacetohydrazide

There total 2 articles about N-(4-methoxyphenyl)piperazineacetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[4-(4-methoxy-phenyl)-piperazin-1-yl]-acetic acid ethyl ester (68104-68-7) → N-(4-methoxyphenyl)piperazineacetohydrazide (68104-78-9)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 12h;

DOI:10.1016/j.bioorg.2021.105430

Reference yield:

4-(4-methoxyphenyl)piperazine (38212-30-5) → N-(4-methoxyphenyl)piperazineacetohydrazide (68104-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 8 h / Reflux

2: hydrazine hydrate / ethanol / 12 h / 20 °C

With potassium carbonate; hydrazine hydrate; In ethanol; acetone;

DOI:10.1016/j.bioorg.2021.105430

Reference yield: 90.0%

2, 4-dichlorophenyl isothiocyanate (6590-96-1) + N-(4-methoxyphenyl)piperazineacetohydrazide (68104-78-9) → 4-(2,4-dichlorophenyl)-1-[4-(4-methoxyphenyl)piperazineacetyl]semicarbazide (204973-91-1)

Guidance literature:

In ethanol; for 0.5h; Heating;

DOI:10.1111/j.2042-7158.1998.tb03313.x

upstream raw materials:

4-(4-methoxyphenyl)piperazine

[4-(4-methoxy-phenyl)-piperazin-1-yl]-acetic acid ethyl ester

Downstream raw materials:

3-[({[4-(4-methoxy-phenyl)-piperazin-1-yl]-acetyl}-hydrazono)-methyl]-rifamycin

4-(2,4-dichlorophenyl)-1-[4-(4-methoxyphenyl)piperazineacetyl]semicarbazide

5-phenyl-3-<(4-methoxyphenyl)piperazin-1-yl-methyl>-1H-1,2,4-triazole

5-(3-methylphenyl)-3-<4-(4-methoxyphenyl)piperazin-1-yl-methyl>-1H-1,2,4-triazole

Refernces