N-(4-fluorobenzyl)-N-methyl-1-(1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-5-yl)methanamine

Base Information

Chemical Name:N-(4-fluorobenzyl)-N-methyl-1-(1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-5-yl)methanamine
CAS No.:1417526-53-4
Molecular Formula:C₂₆H₂₃F₄N₃
Molecular Weight:453.482
Hs Code.:

Synonyms:N-(4-fluorobenzyl)-N-methyl-1-(1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-5-yl)methanamine

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Chemical Property of N-(4-fluorobenzyl)-N-methyl-1-(1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-5-yl)methanamine

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Technology Process of N-(4-fluorobenzyl)-N-methyl-1-(1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-5-yl)methanamine

There total 4 articles about N-(4-fluorobenzyl)-N-methyl-1-(1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-5-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1417526-52-3
5-(chloromethyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole hydrochloride

: 405-66-3
(4-Fluoro-benzyl)-methyl-amine

: 1417526-53-4
N-(4-fluorobenzyl)-N-methyl-1-(1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-5-yl)methanamine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 70 - 80 ℃;

Reference yield:

: 220364-22-7
1-(4-Bromobenzyl)-5-hydroxymethyl-1H-imidazole

: 1417526-53-4
N-(4-fluorobenzyl)-N-methyl-1-(1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-5-yl)methanamine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 15 h / Inert atmosphere; Reflux

2: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 2.17 h / 20 °C / Cooling with ice

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 70 - 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; acetonitrile;

Reference yield:

: 312936-79-1
(1-((4’-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-5-yl)methanol

: 1417526-53-4
N-(4-fluorobenzyl)-N-methyl-1-(1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-5-yl)methanamine

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 2.17 h / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 70 - 80 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane; acetonitrile;