N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-1-methyl-1H-imidazole-4-sulfonamide

Base Information

Chemical Name:N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-1-methyl-1H-imidazole-4-sulfonamide
CAS No.:1380228-38-5
Molecular Formula:C₂₀H₁₅F₂N₉O₂S
Molecular Weight:483.461
Hs Code.:

Synonyms:N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-1-methyl-1H-imidazole-4-sulfonamide

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Chemical Property of N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-1-methyl-1H-imidazole-4-sulfonamide

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Technology Process of N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-1-methyl-1H-imidazole-4-sulfonamide

There total 12 articles about N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-1-methyl-1H-imidazole-4-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1380229-01-5
N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-1-methyl-1H-imidazole-4-sulfonamide

: 1380228-38-5
N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-1-methyl-1H-imidazole-4-sulfonamide

Guidance literature:: N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-1-methyl-1H-imidazole-4-sulfonamide; With hydrogenchloride; In water; for 2h;

With sodium carbonate; In water;

Reference yield:

: 385-00-2
2,6-difluorobenzoic acid

: 1380228-38-5
N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-1-methyl-1H-imidazole-4-sulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid; potassium nitrate / 24 h / 0 - 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C

3.1: sodium azide / dichloromethane / 0.5 h / 20 °C

3.2: 3 h / Reflux

4.1: palladium on activated charcoal; hydrogen / methanol / 15 h

5.1: pyridine / dichloromethane / 2 h / 50 °C

6.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 5 h / 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 20 °C

8.1: hydrogenchloride / water / 2 h

With pyridine; hydrogenchloride; sodium azide; oxalyl dichloride; sulfuric acid; palladium on activated charcoal; hydrogen; potassium nitrate; N,N-dimethyl-formamide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 260552-98-5
2,6-difluoro-3-nitrobenzoic acid chloride

: 1380228-38-5
N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-1-methyl-1H-imidazole-4-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium azide / dichloromethane / 0.5 h / 20 °C

1.2: 3 h / Reflux

2.1: palladium on activated charcoal; hydrogen / methanol / 15 h

3.1: pyridine / dichloromethane / 2 h / 50 °C

4.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 5 h / 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 20 °C

6.1: hydrogenchloride / water / 2 h

With pyridine; hydrogenchloride; sodium azide; palladium on activated charcoal; hydrogen; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate;