N₃-(1-adamantyl)-1-pentyl-6-phenyl-4-thioxo-1,4-dihydropyridine-3-carboxamide

Base Information

Chemical Name:N₃-(1-adamantyl)-1-pentyl-6-phenyl-4-thioxo-1,4-dihydropyridine-3-carboxamide
CAS No.:1256382-79-2
Molecular Formula:C₂₇H₃₄N₂OS
Molecular Weight:434.646
Hs Code.:

N<sub>3</sub>-(1-adamantyl)-1-pentyl-6-phenyl-4-thioxo-1,4-dihydropyridine-3-carboxamide

Synonyms:N₃-(1-adamantyl)-1-pentyl-6-phenyl-4-thioxo-1,4-dihydropyridine-3-carboxamide

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Chemical Property of N₃-(1-adamantyl)-1-pentyl-6-phenyl-4-thioxo-1,4-dihydropyridine-3-carboxamide

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Technology Process of N₃-(1-adamantyl)-1-pentyl-6-phenyl-4-thioxo-1,4-dihydropyridine-3-carboxamide

There total 6 articles about N₃-(1-adamantyl)-1-pentyl-6-phenyl-4-thioxo-1,4-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1256382-56-5
1-pentyl-6-phenyl-4-thioxo-1,4-dihydropyridine-3-carboxylic acid

: 665-66-7,13878-11-0
amantadine hydrochloride

: 1256382-79-2
N₃-(1-adamantyl)-1-pentyl-6-phenyl-4-thioxo-1,4-dihydropyridine-3-carboxamide

Guidance literature:: 1-pentyl-6-phenyl-4-thioxo-1,4-dihydropyridine-3-carboxylic acid; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

amantadine hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jm100286k

Reference yield:

: 1256382-37-2
ethyl 4-oxo-1-pentyl-6-phenyl-1,4-dihydropyridine-3-carboxylate

: 1256382-79-2
N₃-(1-adamantyl)-1-pentyl-6-phenyl-4-thioxo-1,4-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; tetraphosphorus decasulfide / 12 h / Reflux

2.1: sodium hydroxide / ethanol / 6 h / Reflux

2.2: pH 2

3.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

3.2: 12 h / 20 °C

With pyridine; tetraphosphorus decasulfide; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm100286k

Reference yield:

: 1256382-46-3
ethyl 1-pentyl-6-phenyl-4-thioxo-1,4-dihydropyridine-3-carboxylate

: 1256382-79-2
N₃-(1-adamantyl)-1-pentyl-6-phenyl-4-thioxo-1,4-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol / 6 h / Reflux

1.2: pH 2

2.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

2.2: 12 h / 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm100286k