N-[2-Chloro-4-[[2,3-dihydro-2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-3-yl]methyl]-5-methoxyphenyl]-4-morpholineacetamide

Base Information

Chemical Name:N-[2-Chloro-4-[[2,3-dihydro-2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-3-yl]methyl]-5-methoxyphenyl]-4-morpholineacetamide
CAS No.:202822-91-1
Molecular Formula:C₂₃H₂₂ClF₃N₄O₅
Molecular Weight:526.9
Hs Code.:

Synonyms:N-[2-Chloro-4-[[2,3-dihydro-2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-3-yl]methyl]-5-methoxyphenyl]-4-morpholineacetamide

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Chemical Property of N-[2-Chloro-4-[[2,3-dihydro-2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-3-yl]methyl]-5-methoxyphenyl]-4-morpholineacetamide

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Technology Process of N-[2-Chloro-4-[[2,3-dihydro-2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-3-yl]methyl]-5-methoxyphenyl]-4-morpholineacetamide

There total 3 articles about N-[2-Chloro-4-[[2,3-dihydro-2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-3-yl]methyl]-5-methoxyphenyl]-4-morpholineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 110-91-8,99108-56-2
morpholine

: 202822-90-0
2-bromo-N-{2-chloro-5-methoxy-4-[2-oxo-5-(4-trifluoromethyl-phenyl)-[1,3,4]oxadiazol-3-ylmethyl]-phenyl}-acetamide

: 202822-91-1
N-[2-Chloro-4-[[2,3-dihydro-2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-3-yl]methyl]-5-methoxyphenyl]-4-morpholineacetamide

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; for 3.5h; Heating;
DOI:10.1021/jm061006n

Reference yield:

: [3-[(4-amino-5-chloro-2-methoxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]]-1,3,4-oxadiazol-2-(3H)-one

: 202822-91-1
N-[2-Chloro-4-[[2,3-dihydro-2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-3-yl]methyl]-5-methoxyphenyl]-4-morpholineacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / pyridine / tetrahydrofuran / 18 h / 0 °C

2: 90 percent / K₂CO₃; KI / acetonitrile / 3.5 h / Heating

With pyridine; potassium carbonate; potassium iodide; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm061006n