2-(3,5-dibromo-4-((3,5-difluorobenzyl)(4-(2-fluorophenoxy)benzyl)amino)phenyl)acetic acid

Base Information

Chemical Name:2-(3,5-dibromo-4-((3,5-difluorobenzyl)(4-(2-fluorophenoxy)benzyl)amino)phenyl)acetic acid
CAS No.:1398089-52-5
Molecular Formula:C₂₈H₂₀Br₂F₃NO₃
Molecular Weight:635.275
Hs Code.:

Synonyms:2-(3,5-dibromo-4-((3,5-difluorobenzyl)(4-(2-fluorophenoxy)benzyl)amino)phenyl)acetic acid

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Chemical Property of 2-(3,5-dibromo-4-((3,5-difluorobenzyl)(4-(2-fluorophenoxy)benzyl)amino)phenyl)acetic acid

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Technology Process of 2-(3,5-dibromo-4-((3,5-difluorobenzyl)(4-(2-fluorophenoxy)benzyl)amino)phenyl)acetic acid

There total 5 articles about 2-(3,5-dibromo-4-((3,5-difluorobenzyl)(4-(2-fluorophenoxy)benzyl)amino)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1398090-01-1
C₃₀H₂₄Br₂F₃NO₃

: 1398089-52-5
2-(3,5-dibromo-4-((3,5-difluorobenzyl)(4-(2-fluorophenoxy)benzyl)amino)phenyl)acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; water; at 26 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.07.078

Reference yield:

: 936343-96-3
4-(2-fluorophenoxy)benzaldehyde

: 1398089-52-5
2-(3,5-dibromo-4-((3,5-difluorobenzyl)(4-(2-fluorophenoxy)benzyl)amino)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / 1,2-dichloro-ethane / 80 - 85 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 24 h / 26 °C / Inert atmosphere

3: diisopropylamine / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

4: water; lithium hydroxide / tetrahydrofuran; water / 24 h / 26 °C / Inert atmosphere

With water; sodium tris(acetoxy)borohydride; acetic acid; diisopropylamine; lithium hydroxide; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.07.078

Reference yield:

: 1398091-13-8
C₁₀H₁₁Br₂NO₂*ClH

: 1398089-52-5
2-(3,5-dibromo-4-((3,5-difluorobenzyl)(4-(2-fluorophenoxy)benzyl)amino)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / 1,2-dichloro-ethane / 80 - 85 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 24 h / 26 °C / Inert atmosphere

3: diisopropylamine / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

4: water; lithium hydroxide / tetrahydrofuran; water / 24 h / 26 °C / Inert atmosphere

With water; sodium tris(acetoxy)borohydride; acetic acid; diisopropylamine; lithium hydroxide; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.07.078