2-(4-Bromo-2-methylphenyl)ethynyl-trimethylsilane

Base Information

Chemical Name:2-(4-Bromo-2-methylphenyl)ethynyl-trimethylsilane
CAS No.:221292-47-3
Molecular Formula:C₁₂H₁₅BrSi
Molecular Weight:267.241
Hs Code.:
DSSTox Substance ID:DTXSID00443498
Wikidata:Q82261363

Synonyms:AGN-PC-0N8RZ3;221292-47-3;DTXSID00443498

Suppliers and Price of 2-(4-Bromo-2-methylphenyl)ethynyl-trimethylsilane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-Bromo-2-methylphenyl)ethynyl-trimethylsilane

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:0
Rotatable Bond Count:2
Exact Mass:266.01264
Heavy Atom Count:14
Complexity:253

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C=CC(=C1)Br)C#C[Si](C)(C)C

Technology Process of 2-(4-Bromo-2-methylphenyl)ethynyl-trimethylsilane

There total 2 articles about 2-(4-Bromo-2-methylphenyl)ethynyl-trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 116632-39-4
2-methyl-4-bromoiodobenzene

: 1066-54-2
trimethylsilylacetylene

: 221292-47-3
((4-bromo-2-methylphenyl)ethynyl)trimethylsilane

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine; for 20h; Inert atmosphere; Glovebox; Schlenk technique;
DOI:10.1002/bkcs.12149

Reference yield:

: 591-17-3
meta-bromotoluene

: 221292-47-3
((4-bromo-2-methylphenyl)ethynyl)trimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1: 53.8 percent / AlCl₃ / CH₂Cl₂ / Ambient temperature

2: 1.) LDA, diethyl chlorophosphate, 2.) LDA / 1.) THF, -78 deg C, 15 min, then room temp., 3 h, 2.) THF, room temp., overnight

With aluminium trichloride; diethyl chlorophosphate; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jo982392m