2,2-difluoro-1,3-dimethyl-4-[4'-propyl-1,1'-bi(cyclohexyl)-4-yl]imidazolidine

Base Information

Chemical Name:2,2-difluoro-1,3-dimethyl-4-[4'-propyl-1,1'-bi(cyclohexyl)-4-yl]imidazolidine
CAS No.:1455481-83-0
Molecular Formula:C₂₀H₃₆F₂N₂
Molecular Weight:342.516
Hs Code.:

Synonyms:2,2-difluoro-1,3-dimethyl-4-[4'-propyl-1,1'-bi(cyclohexyl)-4-yl]imidazolidine

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Chemical Property of 2,2-difluoro-1,3-dimethyl-4-[4'-propyl-1,1'-bi(cyclohexyl)-4-yl]imidazolidine

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Technology Process of 2,2-difluoro-1,3-dimethyl-4-[4'-propyl-1,1'-bi(cyclohexyl)-4-yl]imidazolidine

There total 8 articles about 2,2-difluoro-1,3-dimethyl-4-[4'-propyl-1,1'-bi(cyclohexyl)-4-yl]imidazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1455481-79-4
2-chloro-1,3-dimethyl-4-[4'-propyl-1,1'-bi(cyclohexyl)-4-yl]-4,5-dihydro-1H-imidazol-3-ium chloride

: 1455481-83-0
2,2-difluoro-1,3-dimethyl-4-[4'-propyl-1,1'-bi(cyclohexyl)-4-yl]imidazolidine

Guidance literature:: With potassium fluoride; In acetonitrile; at 85 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.tet.2013.07.062

Reference yield:

: 477557-80-5
1'-propyl-4-vinyl-1,4'-bicyclohexane

: 1455481-83-0
2,2-difluoro-1,3-dimethyl-4-[4'-propyl-1,1'-bi(cyclohexyl)-4-yl]imidazolidine

Guidance literature:: Multi-step reaction with 8 steps

1.1: bromine / hexane / 20 °C / Inert atmosphere

2.1: sodium azide / dimethyl sulfoxide / 10 h / 95 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

4.1: chloroform / 24 h / Inert atmosphere; Reflux

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 15 h / Inert atmosphere; Reflux

6.1: n-butyllithium / tetrahydrofuran; hexane / 20 °C / Inert atmosphere

6.2: -30 - 20 °C / Inert atmosphere

7.1: oxalyl dichloride / toluene / 12 h / 80 °C / Inert atmosphere

8.1: potassium fluoride / acetonitrile / 12 h / 85 °C / Inert atmosphere

With potassium fluoride; lithium aluminium tetrahydride; n-butyllithium; sodium azide; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; bromine; In tetrahydrofuran; ethanol; hexane; chloroform; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1016/j.tet.2013.07.062

Reference yield:

: 1455481-66-9
N,N'-1-[4'-(propylbi(cyclohexan)-4-yl)ethane-1,2-diyl]diformamide

: 1455481-83-0
2,2-difluoro-1,3-dimethyl-4-[4'-propyl-1,1'-bi(cyclohexyl)-4-yl]imidazolidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 15 h / Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 20 °C / Inert atmosphere

2.2: -30 - 20 °C / Inert atmosphere

3.1: oxalyl dichloride / toluene / 12 h / 80 °C / Inert atmosphere

4.1: potassium fluoride / acetonitrile / 12 h / 85 °C / Inert atmosphere

With potassium fluoride; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; In tetrahydrofuran; hexane; toluene; acetonitrile;
DOI:10.1016/j.tet.2013.07.062