Oxiranecarboxamide, 3-methyl-N-[1-methyl-2-(1-piperidinyl)ethyl]-, (2S,3R)- (9CI)

Base Information

• Chemical Name: Oxiranecarboxamide, 3-methyl-N-[1-methyl-2-(1-piperidinyl)ethyl]-, (2S,3R)- (9CI)
• CAS No.: 791855-86-2
• Molecular Formula: C₁₂H₂₂N₂O₂
• Molecular Weight: 226.319
• Mol file: 791855-86-2.mol

Synonyms:Oxiranecarboxamide,3-methyl-N-[1-methyl-2-(1-piperidinyl)ethyl]-, (2S,3R)- (9CI)

Chemical Property of Oxiranecarboxamide, 3-methyl-N-[1-methyl-2-(1-piperidinyl)ethyl]-, (2S,3R)- (9CI)

Chemical Property:

• Boiling Point: 402.9±45.0 °C(Predicted)
• PKA: 14.59±0.40(Predicted)
• PSA: 44.87000
• Density: 1.071±0.06 g/cm3(Predicted)
• LogP: 1.09310

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of Oxiranecarboxamide, 3-methyl-N-[1-methyl-2-(1-piperidinyl)ethyl]-, (2S,3R)- (9CI)

There total 1 articles about Oxiranecarboxamide, 3-methyl-N-[1-methyl-2-(1-piperidinyl)ethyl]-, (2S,3R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1R-methyl-2-piperidin-1-yl-ethylamine (34217-60-2) + (2S)-trans-2,3-epoxybutanoic acid (13737-03-6) → (2S,3R)-3-Methyl-oxirane-2-carboxylic acid (1-methyl-2-piperidin-1-yl-ethyl)-amide (791855-86-2)

Guidance literature:

With PS-DCC; benzotriazol-1-ol; In tetrahydrofuran;

DOI:10.1016/j.tet.2004.07.085

Reference yield:

(2S,3R)-3-Methyl-oxirane-2-carboxylic acid (1-methyl-2-piperidin-1-yl-ethyl)-amide (791855-86-2) + 2-fluorobenzonitrile (394-47-8) → (4S,5S)-2-(2-Fluoro-phenyl)-4-methyl-4,5-dihydro-oxazole-5-carboxylic acid (1-methyl-2-piperidin-1-yl-ethyl)-amide

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.tet.2004.07.085

Reference yield:

(2S,3R)-3-Methyl-oxirane-2-carboxylic acid (1-methyl-2-piperidin-1-yl-ethyl)-amide (791855-86-2) + trans-2-cyanocyclohexanol (63301-31-5,125291-55-6) → (4S,5S)-2-(2-Hydroxy-cyclohexyl)-4-methyl-4,5-dihydro-oxazole-5-carboxylic acid (1-methyl-2-piperidin-1-yl-ethyl)-amide

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.tet.2004.07.085

upstream raw materials:

1R-methyl-2-piperidin-1-yl-ethylamine

(2S)-trans-2,3-epoxybutanoic acid

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