O-2-cyanoethyl O'-{2-[4-((4,4'-dimethoxytriphenylmethyloxy)hex-1-yn-1-yl)]-7-(hex-5-yn-1-yl)fluorene}-N,N-diisopropyl phosphoramidite

Base Information

Chemical Name:O-2-cyanoethyl O'-{2-[4-((4,4'-dimethoxytriphenylmethyloxy)hex-1-yn-1-yl)]-7-(hex-5-yn-1-yl)fluorene}-N,N-diisopropyl phosphoramidite
CAS No.:1291078-53-9
Molecular Formula:C₅₅H₆₁N₂O₅P
Molecular Weight:861.073
Hs Code.:

Synonyms:O-2-cyanoethyl O'-{2-[4-((4,4'-dimethoxytriphenylmethyloxy)hex-1-yn-1-yl)]-7-(hex-5-yn-1-yl)fluorene}-N,N-diisopropyl phosphoramidite

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Chemical Property of O-2-cyanoethyl O'-{2-[4-((4,4'-dimethoxytriphenylmethyloxy)hex-1-yn-1-yl)]-7-(hex-5-yn-1-yl)fluorene}-N,N-diisopropyl phosphoramidite

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Technology Process of O-2-cyanoethyl O'-{2-[4-((4,4'-dimethoxytriphenylmethyloxy)hex-1-yn-1-yl)]-7-(hex-5-yn-1-yl)fluorene}-N,N-diisopropyl phosphoramidite

There total 4 articles about O-2-cyanoethyl O'-{2-[4-((4,4'-dimethoxytriphenylmethyloxy)hex-1-yn-1-yl)]-7-(hex-5-yn-1-yl)fluorene}-N,N-diisopropyl phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1291078-49-3
2-[6-(4,4'-dimethoxytriphenylmethyloxy)hex-1-yn-1-yl]-7-(6-hydroxyhex-1-yn-1-yl)fluorene

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1291078-53-9
O-2-cyanoethyl O'-{2-[4-((4,4'-dimethoxytriphenylmethyloxy)hex-1-yn-1-yl)]-7-(hex-5-yn-1-yl)fluorene}-N,N-diisopropyl phosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1039/c0cc05125j

Reference yield:

: 928-90-5
5-hexyl-1-ol

: 1291078-53-9
O-2-cyanoethyl O'-{2-[4-((4,4'-dimethoxytriphenylmethyloxy)hex-1-yn-1-yl)]-7-(hex-5-yn-1-yl)fluorene}-N,N-diisopropyl phosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / Reflux

2: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1: Sonogashira coupling;
DOI:10.1039/c0cc05125j

Reference yield:

: 16433-88-8
2,7-dibromo-9H-fluorene

: 1291078-53-9
O-2-cyanoethyl O'-{2-[4-((4,4'-dimethoxytriphenylmethyloxy)hex-1-yn-1-yl)]-7-(hex-5-yn-1-yl)fluorene}-N,N-diisopropyl phosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / Reflux

2: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1: Sonogashira coupling;
DOI:10.1039/c0cc05125j