Technology Process of 4-allyl-4-[(allyloxy)methyl]-2-benzyl-1,2,3,4-tetrahydroisoquinoline
There total 7 articles about 4-allyl-4-[(allyloxy)methyl]-2-benzyl-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: acetic acid / methanol / 0.5 h / 20 °C / Inert atmosphere
1.2: 24 h / 65 °C / Inert atmosphere
2.1: 24 h / 110 °C / Inert atmosphere; Neat (no solvent)
3.1: palladium diacetate; caesium carbonate; triphenylphosphine / toluene / 24 h / 80 °C / Inert atmosphere
4.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -15 °C / Inert atmosphere
4.2: 4 h / -15 - 20 °C / Inert atmosphere
5.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere
6.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; palladium diacetate; sodium hydride; caesium carbonate; acetic acid; triphenylphosphine; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; diethyl ether; hexane; N,N-dimethyl-formamide; toluene;
2.1: Michael addition / 3.1: Buchwald-Hartwig α arylation;
DOI:10.1016/j.tet.2012.06.106
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -15 °C / Inert atmosphere
1.2: 4 h / -15 - 20 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.06.106
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: palladium diacetate; caesium carbonate; triphenylphosphine / toluene / 24 h / 80 °C / Inert atmosphere
2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -15 °C / Inert atmosphere
2.2: 4 h / -15 - 20 °C / Inert atmosphere
3.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere
4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; palladium diacetate; sodium hydride; caesium carbonate; triphenylphosphine; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide; toluene;
1.1: Buchwald-Hartwig α arylation;
DOI:10.1016/j.tet.2012.06.106
