H-LEU-PHE-NH2 HCL

Base Information

• Chemical Name: H-LEU-PHE-NH2 HCL
• CAS No.: 74214-38-3
• Molecular Formula: C15H23 N3 O2 . Cl H
• Molecular Weight: 313.82
• Mol file: 74214-38-3.mol

Synonyms:L-Phenylalaninamide,L-leucyl-, monohydrochloride (9CI); L-Leucyl-L-phenylalaninamide hydrochloride

Chemical Property of H-LEU-PHE-NH2 HCL

Chemical Property:

• PSA: 98.21000
• LogP: 3.16610
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

H-Leu-Phe-NH2hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: H-Leu-Phe-NH2 HCl

Technology Process of H-LEU-PHE-NH2 HCL

There total 3 articles about H-LEU-PHE-NH2 HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.8%

(2S)-N-[(1S)-2-amino-1-benzyl-2-oxoethyl]-2-[(tert-butoxycarbonyl)amino]-4-methylpentanamide (33900-15-1) → L-leucyl-L-phenylalaninamide hydrochloride (74214-38-3)

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 0.75h; Ambient temperature;

DOI:10.1021/jm00392a016

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → L-leucyl-L-phenylalaninamide hydrochloride (74214-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 17.6 g / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide (DCC) / dimethylformamide; CH₂Cl₂ / 18 h / 0 °C

2: HCl / ethyl acetate / 1 h / 0 °C

With hydrogenchloride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm00150a007

Reference yield:

L-Phenylalanine amide (5241-58-7) → L-leucyl-L-phenylalaninamide hydrochloride (74214-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 17.6 g / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide (DCC) / dimethylformamide; CH₂Cl₂ / 18 h / 0 °C

2: HCl / ethyl acetate / 1 h / 0 °C

With hydrogenchloride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm00150a007

upstream raw materials:

(2S)-N-[(1S)-2-amino-1-benzyl-2-oxoethyl]-2-[(tert-butoxycarbonyl)amino]-4-methylpentanamide

N-tert-butoxycarbonyl-L-leucine

L-Phenylalanine amide

Downstream raw materials:

Boc-His-Sta-Leu-Phe-NH₂

Nα-[3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)uridin-2'-O-ylcarbonyl]-L-leucyl-L-phenylalaninamide

<4(S)-amino-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide trifluoroacetate

Boc-Phe-His-Sta-Leu-Phe-NH₂

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