(R)-N-(4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)(methyl)amino)pent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:(R)-N-(4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)(methyl)amino)pent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide
CAS No.:1346655-28-4
Molecular Formula:C₃₁H₃₈F₃N₃O₄Si
Molecular Weight:601.741
Hs Code.:

(R)-N-(4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)(methyl)amino)pent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

Synonyms:(R)-N-(4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)(methyl)amino)pent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

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Chemical Property of (R)-N-(4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)(methyl)amino)pent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

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Technology Process of (R)-N-(4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)(methyl)amino)pent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

There total 4 articles about (R)-N-(4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)(methyl)amino)pent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346424-49-4
N-(4-(5-bromopent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

: 1346654-59-8
(R)-5-(1-((tert-butyldimethylsilyl)oxy)-2-(methylamino)ethyl)-8-hydroxyquinolin-2(1H)-one

: 1346655-28-4
(R)-N-(4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)(methyl)amino)pent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; at 55 ℃; for 72h;

Reference yield:

: 530084-74-3
(R)-8-(benzyloxy)-5-(2-bromo-1-((tert-butyldimethylsilyl)oxy)ethyl)quinolin-2(1H)-one

: 1346655-28-4
(R)-N-(4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)(methyl)amino)pent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 72 h / 100 °C / Sealed tube

2: hydrogen; palladium 10% on activated carbon / methanol / 7 h

3: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / 72 h / 55 °C

With palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;

Reference yield:

: 1346424-48-3
N-(4-(5-chloropent-1-ynyl)phenyl)-2,2,2-trifluoroacetamide

: 1346655-28-4
(R)-N-(4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)(methyl)amino)pent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium bromide / pentan-3-one / 20 h / Reflux

2: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / 72 h / 55 °C

With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; lithium bromide; In pentan-3-one;