ethyl 5-amino-2,6-dimethyl-4-phenylnicotinate

Base Information

• Chemical Name: ethyl 5-amino-2,6-dimethyl-4-phenylnicotinate
• CAS No.: 861044-92-0
• Molecular Formula: C₁₆H₁₈N₂O₂
• Molecular Weight: 270.331
• Mol file: 861044-92-0.mol

Synonyms:ethyl 5-amino-2,6-dimethyl-4-phenylnicotinate

Chemical Property of ethyl 5-amino-2,6-dimethyl-4-phenylnicotinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-amino-2,6-dimethyl-4-phenylnicotinate

There total 3 articles about ethyl 5-amino-2,6-dimethyl-4-phenylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2,6-dimethyl-3-nitro-4-phenyl-5-ethoxycarbonylpyridine → ethyl 5-amino-2,6-dimethyl-4-phenylnicotinate (861044-92-0)

Guidance literature:

With tin(II) chloride dihdyrate; In ethanol; for 3h; Reflux;

DOI:10.1007/s10593-021-02892-9

Reference yield:

5-carbamoyl-2,6-dimethyl-4-phenyl-nicotinic acid ethyl ester (143755-77-5) → ethyl 5-amino-2,6-dimethyl-4-phenylnicotinate (861044-92-0)

Guidance literature:

With potassium hydroxide; potassium hypobromite;

DOI:10.1039/jr9460000200

Reference yield:

2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid monoethyl ester (57097-51-5) → ethyl 5-amino-2,6-dimethyl-4-phenylnicotinate (861044-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / Behandeln des erhaltenen Saeurechlorids in Benzol mit wss. NH₃

2: KBrO; aqueous KOH

With potassium hydroxide; thionyl chloride; potassium hypobromite;

DOI:10.1039/jr9460000200

upstream raw materials:

5-carbamoyl-2,6-dimethyl-4-phenyl-nicotinic acid ethyl ester

2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid monoethyl ester

Downstream raw materials:

5-benzoylamino-2,6-dimethyl-4-phenyl-nicotinic acid ethyl ester