2-(5-Nitro-2-(5-tert-butyldimethylsilyloxy)-pentylthiophenylmethylene)-3-oxobutanoic acid, 2-(trimethylsilyl)ethyl ester

Base Information

• Chemical Name: 2-(5-Nitro-2-(5-tert-butyldimethylsilyloxy)-pentylthiophenylmethylene)-3-oxobutanoic acid, 2-(trimethylsilyl)ethyl ester
• CAS No.: 145457-78-9
• Molecular Formula: C₂₇H₄₅NO₆SSi₂
• Molecular Weight: 567.894

Synonyms:2-(5-Nitro-2-(5-tert-butyldimethylsilyloxy)-pentylthiophenylmethylene)-3-oxobutanoic acid, 2-(trimethylsilyl)ethyl ester

Chemical Property of 2-(5-Nitro-2-(5-tert-butyldimethylsilyloxy)-pentylthiophenylmethylene)-3-oxobutanoic acid, 2-(trimethylsilyl)ethyl ester

Chemical Property:

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Technology Process of 2-(5-Nitro-2-(5-tert-butyldimethylsilyloxy)-pentylthiophenylmethylene)-3-oxobutanoic acid, 2-(trimethylsilyl)ethyl ester

There total 3 articles about 2-(5-Nitro-2-(5-tert-butyldimethylsilyloxy)-pentylthiophenylmethylene)-3-oxobutanoic acid, 2-(trimethylsilyl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(Trimethylsilyl)ethanol (2916-68-9) → 2-(5-Nitro-2-(5-tert-butyldimethylsilyloxy)-pentylthiophenylmethylene)-3-oxobutanoic acid, 2-(trimethylsilyl)ethyl ester (145457-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / toluene / 90 °C

2: acetic acid, piperidine / benzene / 1 h / Heating

With piperidine; sodium acetate; acetic acid; In toluene; benzene;

DOI:10.1021/jm00001a017

Reference yield:

2-(trimethylsilyl)ethyl acetoacetate (17165-45-6) + 2-[5-(tert-Butyl-dimethyl-silanyloxy)-pentylsulfanyl]-5-nitro-benzaldehyde → 2-(5-Nitro-2-(5-tert-butyldimethylsilyloxy)-pentylthiophenylmethylene)-3-oxobutanoic acid, 2-(trimethylsilyl)ethyl ester (145457-78-9)

Guidance literature:

With piperidine; acetic acid; In benzene; for 1h; Heating;

DOI:10.1021/jm00001a017

Reference yield:

→ 2-(5-Nitro-2-(5-tert-butyldimethylsilyloxy)-pentylthiophenylmethylene)-3-oxobutanoic acid, 2-(trimethylsilyl)ethyl ester (145457-78-9)

Guidance literature:

upstream raw materials:

2-(trimethylsilyl)ethyl acetoacetate

2-(Trimethylsilyl)ethanol

Downstream raw materials:

1,4-Dihydro-6-methyl-2-(methylthio)-4-(2-(5-tert-butyldimethylsilyloxypentylthio)-5-nitro-phenyl)-5-pyrimidinecarboxylic acid, 2-(trimethylsilyl)ethyl ester

6-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-pentylsulfanyl]-5-nitro-phenyl}-4-methyl-2-methylsulfanyl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-(2-trimethylsilanyl-ethyl) ester

6-[2-(5-Hydroxy-pentylsulfanyl)-5-nitro-phenyl]-4-methyl-2-methylsulfanyl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester

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