cyclohexanecarboxylic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide

Base Information

Chemical Name:cyclohexanecarboxylic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide
CAS No.:1613639-70-5
Molecular Formula:C₂₀H₂₄BrN₃O
Molecular Weight:402.334
Hs Code.:

Synonyms:cyclohexanecarboxylic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide

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Chemical Property of cyclohexanecarboxylic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide

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Technology Process of cyclohexanecarboxylic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide

There total 5 articles about cyclohexanecarboxylic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613639-55-6
(R)-N-(5-bromopyridin-3-yl)-1-phenylethane-1,2-diamine

: 2719-27-9
cyclohexanylcarbonyl chloride

: 1613639-70-5
cyclohexanecarboxylic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 875-74-1
(R)-phenylglycine

: 1613639-70-5
cyclohexanecarboxylic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide

Guidance literature:: Multi-step reaction with 4 steps

1: L-proline; potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: hydrazine hydrate / ethanol / 1 h / 80 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; L-proline; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; 2: |Mitsunobu Displacement;

Reference yield:

: 625-92-3
3,5-dibromopyridine

: 1613639-70-5
cyclohexanecarboxylic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide

Guidance literature:: Multi-step reaction with 4 steps

1: L-proline; potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: hydrazine hydrate / ethanol / 1 h / 80 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; L-proline; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; 2: |Mitsunobu Displacement;