3-(5-((R)-2-tert-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazo1-2-yl)-N-methyl-N-(methylsulfonyl)-5-(1-trityl-1H-imidazol-4-yl)benzenamine

Base Information

• Chemical Name: 3-(5-((R)-2-tert-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazo1-2-yl)-N-methyl-N-(methylsulfonyl)-5-(1-trityl-1H-imidazol-4-yl)benzenamine
• CAS No.: 868287-70-1
• Molecular Formula: C₄₆H₄₆N₆O₅S
• Molecular Weight: 794.974
• Mol file: 868287-70-1.mol

Synonyms:3-(5-((R)-2-tert-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazo1-2-yl)-N-methyl-N-(methylsulfonyl)-5-(1-trityl-1H-imidazol-4-yl)benzenamine

Chemical Property of 3-(5-((R)-2-tert-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazo1-2-yl)-N-methyl-N-(methylsulfonyl)-5-(1-trityl-1H-imidazol-4-yl)benzenamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(5-((R)-2-tert-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazo1-2-yl)-N-methyl-N-(methylsulfonyl)-5-(1-trityl-1H-imidazol-4-yl)benzenamine

There total 1 articles about 3-(5-((R)-2-tert-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazo1-2-yl)-N-methyl-N-(methylsulfonyl)-5-(1-trityl-1H-imidazol-4-yl)benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl [1-(5-{3-bromo-5-[methyl(methylsulfonyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)-(1R)-1-methyl-2-phenylethyl]carbamate (868286-55-9) + N-trityl-4(5)-iodoimidazole (96797-15-8) → 3-(5-((R)-2-tert-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazo1-2-yl)-N-methyl-N-(methylsulfonyl)-5-(1-trityl-1H-imidazol-4-yl)benzenamine (868287-70-1)

Guidance literature:

N-trityl-4⁽⁵⁾-iodoimidazole; With ethylmagnesium bromide; In tetrahydrofuran; at 20 ℃; for 0.5h;

With zinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 1h;

tert-butyl [1-(5-{3-bromo-5-[methyl(methylsulfonyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)-(1R)-1-methyl-2-phenylethyl]carbamate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 80 ℃; for 0.5h; Microwave;

Reference yield:

3-(5-((R)-2-tert-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazo1-2-yl)-N-methyl-N-(methylsulfonyl)-5-(1-trityl-1H-imidazol-4-yl)benzenamine (868287-70-1) + trifluoroacetic acid (76-05-1) → 3-(5-((R)-2-amino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-5-(1H-imidazol-4-yl)-N-methyl-N-(methylsulfonyl)benzenamine trifluoroacetate

Guidance literature:

In dichloromethane; at 20 ℃;

upstream raw materials:

tert-butyl [1-(5-{3-bromo-5-[methyl(methylsulfonyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)-(1R)-1-methyl-2-phenylethyl]carbamate

N-trityl-4⁽⁵⁾-iodoimidazole