1-(3-METHOXY-PHENYL)-CYCLOPROPANECARBOXYLIC ACID

Base Information

• Chemical Name: 1-(3-METHOXY-PHENYL)-CYCLOPROPANECARBOXYLIC ACID
• CAS No.: 74205-29-1
• Molecular Formula: C11H12 O3
• Molecular Weight: 192.214
• Hs Code.: 2918990090
• Mol file: 74205-29-1.mol

Synonyms:1-(3-Methoxyphenyl)cyclopropane-1-carboxylicacid; 1-(3-Methoxyphenyl)cyclopropanecarboxylic acid

Chemical Property of 1-(3-METHOXY-PHENYL)-CYCLOPROPANECARBOXYLIC ACID

Chemical Property:

• PSA: 46.53000
• LogP: 1.81140
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

1-(3-methoxyphenyl)cyclopropanecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-METHOXY-PHENYL)-CYCLOPROPANECARBOXYLIC ACID

There total 3 articles about 1-(3-METHOXY-PHENYL)-CYCLOPROPANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.4%

1-(3-methoxyphenyl)cyclopropanecarbonitrile (74205-01-9) → 1-(3-methoxyphenyl)cyclopropane-1-carboxylic acid (74205-29-1)

Guidance literature:

With potassium hydroxide; In diethylene glycol; for 8h; Heating;

DOI:10.1007/BF00765910

Reference yield:

1-(3-methoxyphenyl)cyclopropanecarbonitrile (74205-01-9) → 1-(3-methoxyphenyl)cyclopropanecarboxamide (940307-91-5) + 1-(3-methoxyphenyl)cyclopropane-1-carboxylic acid (74205-29-1)

Guidance literature:

1-(3-methoxyphenyl)cyclopropanecarbonitrile; With potassium hydroxide; In ethanol; water; for 5h; Heating / reflux;

With hydrogenchloride; In ethanol; water; pH=1 - 2;

Reference yield:

3-methoxyphenylacetonitrile (19924-43-7) → 1-(3-methoxyphenyl)cyclopropane-1-carboxylic acid (74205-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium amide / 1.) toluene, heating, 1 h, 2.) overnight; heating, 6 h

2: 84.4 percent / KOH / bis-(2-hydroxy-ethyl) ether / 8 h / Heating

With potassium hydroxide; sodium amide; In diethylene glycol;

DOI:10.1007/BF00765910

upstream raw materials:

1-(3-methoxyphenyl)cyclopropanecarbonitrile

3-methoxyphenylacetonitrile

Downstream raw materials:

(6R,7R)-7-{[1-(3-Methoxy-phenyl)-cyclopropanecarbonyl]-amino}-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(2S,5R,6R)-6-{[1-(3-Methoxy-phenyl)-cyclopropanecarbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

(4R)-4-[(2-chlorophenyl)sulfonyl]-N-(1-cyanocyclopropyl)-1-{[1-(3-methoxyphenyl)cyclopropyl]carbonyl}-L-prolinamide

(1-(3-methoxyphenyl)cyclopropyl)(trifluoromethyl)sulfane

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