(S)-3-((S)-asparaginylamino)-4-<4'-<(3'-carbethoxypropyl)oxy>phenyl>-1-((S)-N-prolyl-(S)-isoleucyl-(S)-valine amide)-butan-2-ol

Base Information

Chemical Name:(S)-3-((S)-asparaginylamino)-4-<4'-<(3'-carbethoxypropyl)oxy>phenyl>-1-((S)-N-prolyl-(S)-isoleucyl-(S)-valine amide)-butan-2-ol
CAS No.:185303-93-9
Molecular Formula:C₃₄H₅₅N₇O₉
Molecular Weight:705.852
Hs Code.:

Synonyms:(S)-3-((S)-asparaginylamino)-4-<4'-<(3'-carbethoxypropyl)oxy>phenyl>-1-((S)-N-prolyl-(S)-isoleucyl-(S)-valine amide)-butan-2-ol

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Chemical Property of (S)-3-((S)-asparaginylamino)-4-<4'-<(3'-carbethoxypropyl)oxy>phenyl>-1-((S)-N-prolyl-(S)-isoleucyl-(S)-valine amide)-butan-2-ol

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Technology Process of (S)-3-((S)-asparaginylamino)-4-<4'-<(3'-carbethoxypropyl)oxy>phenyl>-1-((S)-N-prolyl-(S)-isoleucyl-(S)-valine amide)-butan-2-ol

There total 4 articles about (S)-3-((S)-asparaginylamino)-4-<4'-<(3'-carbethoxypropyl)oxy>phenyl>-1-((S)-N-prolyl-(S)-isoleucyl-(S)-valine amide)-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[4-((S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-4-{(S)-2-[(1S,2S)-1-((S)-1-carbamoyl-2-methyl-propylcarbamoyl)-2-methyl-butylcarbamoyl]-pyrrolidin-1-yl}-3-hydroxy-butyl)-phenoxy]-butyric acid ethyl ester

: 185303-93-9
(S)-3-((S)-asparaginylamino)-4-<4'-<(3'-carbethoxypropyl)oxy>phenyl>-1-((S)-N-prolyl-(S)-isoleucyl-(S)-valine amide)-butan-2-ol

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; for 0.5h; Yield given; Ambient temperature;
DOI:10.1021/ja00146a007

Reference yield:

: 3978-80-1
Boc-Tyr-OH

: 185303-93-9
(S)-3-((S)-asparaginylamino)-4-<4'-<(3'-carbethoxypropyl)oxy>phenyl>-1-((S)-N-prolyl-(S)-isoleucyl-(S)-valine amide)-butan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: NaH

2: 1.) EtOCOCl, NMP, 3.) HBr

3: 1.) DIPEA, 2.) NaBH₄, 3.) TFA, 4.) HBTU, DIPEA, 5.) HF, 6.) NaOH

With 1-methyl-pyrrolidin-2-one; sodium hydroxide; sodium tetrahydroborate; hydrogen fluoride; hydrogen bromide; chloroformic acid ethyl ester; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
DOI:10.1016/0960-894X(96)00468-4

Reference yield:

: 171858-32-5
ethyl 4-<4'-<<2-<(tert-butoxycarbonyl)amino>-2-carboxy>ethyl>phenoxy>butanoate

: 185303-93-9
(S)-3-((S)-asparaginylamino)-4-<4'-<(3'-carbethoxypropyl)oxy>phenyl>-1-((S)-N-prolyl-(S)-isoleucyl-(S)-valine amide)-butan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) EtOCOCl, NMP, 3.) HBr

2: 1.) DIPEA, 2.) NaBH₄, 3.) TFA, 4.) HBTU, DIPEA, 5.) HF, 6.) NaOH

With 1-methyl-pyrrolidin-2-one; sodium hydroxide; sodium tetrahydroborate; hydrogen fluoride; hydrogen bromide; chloroformic acid ethyl ester; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
DOI:10.1016/0960-894X(96)00468-4