(1S,2R,2'S)-(-)-[2-(benzyloxymethyl)-1-(tert-butyl)hexyl][2'-(methoxymethyl)pyrrolidin-1'-yl]amine

Base Information

Chemical Name:(1S,2R,2'S)-(-)-[2-(benzyloxymethyl)-1-(tert-butyl)hexyl][2'-(methoxymethyl)pyrrolidin-1'-yl]amine
CAS No.:825601-22-7
Molecular Formula:C₂₄H₄₂N₂O₂
Molecular Weight:390.61
Hs Code.:

Synonyms:(1S,2R,2'S)-(-)-[2-(benzyloxymethyl)-1-(tert-butyl)hexyl][2'-(methoxymethyl)pyrrolidin-1'-yl]amine

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Chemical Property of (1S,2R,2'S)-(-)-[2-(benzyloxymethyl)-1-(tert-butyl)hexyl][2'-(methoxymethyl)pyrrolidin-1'-yl]amine

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Technology Process of (1S,2R,2'S)-(-)-[2-(benzyloxymethyl)-1-(tert-butyl)hexyl][2'-(methoxymethyl)pyrrolidin-1'-yl]amine

There total 3 articles about (1S,2R,2'S)-(-)-[2-(benzyloxymethyl)-1-(tert-butyl)hexyl][2'-(methoxymethyl)pyrrolidin-1'-yl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 594-19-4
tert.-butyl lithium

: 825601-09-0
(2R,2S)-(-)-[2-(benzyloxymethyl)hexylidene][2-(methoxymethyl)pyrrolidin-1-yl]amine

: 825601-22-7
(1S,2R,2'S)-(-)-[2-(benzyloxymethyl)-1-(tert-butyl)hexyl][2'-(methoxymethyl)pyrrolidin-1'-yl]amine

Guidance literature:: tert.-butyl lithium; With cerium(III) chloride; In tetrahydrofuran; at -78 ℃; for 2h;

(2R,2S)-(-)-[2-(benzyloxymethyl)hexylidene][2-(methoxymethyl)pyrrolidin-1-yl]amine; In tetrahydrofuran; at -100 - 20 ℃; for 16h;
DOI:10.1002/ejoc.200400473

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 825601-22-7
(1S,2R,2'S)-(-)-[2-(benzyloxymethyl)-1-(tert-butyl)hexyl][2'-(methoxymethyl)pyrrolidin-1'-yl]amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 79 percent / LDA; n-BuLi / tetrahydrofuran / -100 - -65 °C

2.1: CeCl₃ / tetrahydrofuran / 2 h / -78 °C

2.2: 91 percent / tetrahydrofuran / 16 h / -100 - 20 °C

With n-butyllithium; cerium(III) chloride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1002/ejoc.200400473

Reference yield:

: 825600-97-3
Hex-(E)-ylidene-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine

: 825601-22-7
(1S,2R,2'S)-(-)-[2-(benzyloxymethyl)-1-(tert-butyl)hexyl][2'-(methoxymethyl)pyrrolidin-1'-yl]amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 79 percent / LDA; n-BuLi / tetrahydrofuran / -100 - -65 °C

2.1: CeCl₃ / tetrahydrofuran / 2 h / -78 °C

2.2: 91 percent / tetrahydrofuran / 16 h / -100 - 20 °C

With n-butyllithium; cerium(III) chloride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1002/ejoc.200400473